24152-95-2

Usage

Uses

Used in Pharmaceutical Industry:
2-OXO-2-PYRROLIDIN-1-YLETHANAMINE is used as a cognitive enhancer for improving memory, learning, and cognitive function. It is particularly beneficial for the treatment of cognitive disorders such as dementia and Alzheimer's disease, where it can help mitigate the symptoms and slow the progression of these conditions.
Used in Neurological Research:
2-OXO-2-PYRROLIDIN-1-YLETHANAMINE is used as a research compound for studying its neuroprotective and neurotrophic effects. Its potential in treating neurological conditions is being explored, which could lead to the development of new therapies for various brain-related disorders.
Used in Cognitive Health Supplements:
2-OXO-2-PYRROLIDIN-1-YLETHANAMINE is used as an ingredient in cognitive health supplements, aimed at enhancing cognitive performance and supporting brain health in individuals seeking to improve or maintain their cognitive abilities.

InChI:InChI=1/C6H12N2O/c7-5-6(9)8-3-1-2-4-8/h1-5,7H2

Upstream product

• 883554-96-9 tert-butyl N-(2-oxo-2-pyrrolidin-1-yl-ethyl)carbamate 
• 4426-24-8 tris(tetrahydropyrrole)boron 
• 56-40-6 glycine 
• 20266-00-6 chloroacetic acid pyrrolidide 

Downstream Products

• 113273-60-2 N,N-tetramethylene-2-(benzylideneamino)ethanamide 
• 113273-82-8 (2S,3R,5R)-2-Phenyl-5-(pyrrolidine-1-carbonyl)-pyrrolidine-3-carboxylic acid methyl ester 
• 113273-84-0 (2R,3R,5R)-3-Methyl-2-phenyl-5-(pyrrolidine-1-carbonyl)-pyrrolidine-3-carboxylic acid methyl ester 
• 949680-17-5 (2-hydroxyphenyl)[5-(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]methanone 
• 1621421-68-8 tert-butyl 2-(benzyloxymethyl)-2-(2-oxo-2-(pyrrolidin-1-yl)ethylcarbamoyl)pyrrolidine-1-carboxylate 
• 88197-48-2 (E)-1-{4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE

The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme. (in formula [I] above, the structure represented by formula [II] below: represents any of the structures represented by formula group [III] below: R1, R2, R3, and R4 independently represent a hydrogen atom, a fluorine atom, methyl, or the like, R5 represents any of the structures represented by formula group [IV]:

Structure–Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7

SETD7 is a histone H3K4 lysine methyltransferase involved in human gene regulation. Aberrant expression of SETD7 has been associated with various diseases, including cancer. Therefore, SETD7 is considered a good target for the development of new epigenetic drugs. To date, few selective small-molecule inhibitors have been reported that target SETD7, the most potent being (R)-PFI-2. Herein we report structure–activity relationship studies on (R)-PFI-2 and its analogues. A library of 29 structural analogues of (R)-PFI-2 was synthesized and evaluated for inhibition of recombinantly expressed human SETD7. The key interactions were found to be a salt bridge and a hydrogen bond formed between (R)-PFI-2′s NH2+ group and SETD7′s Asp256 and His252 residue, respectively.

AZOLE-SUBSTITUTED PYRIDINE COMPOUND

The present invention provides a compound represented by formula [I'| shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme, wherein the structure represented by formula [III] shown below represents any of the structures represented by formula group [IV] shown below, wherein R1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R2, R3, and R4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C1-3alkanediyl, or the formula -O-CH2CH2-; and ring A represents (a) substituted C4-6cycloalkyl, (b) substituted 4- to 6-membered saturated nitrogen-containing heterocyclyl, (c) substituted phenyl, (d) substituted pyridyl, (e) substituted 2,3-dihydrobenzofuran, (f) 4- to 6-membered saturated oxygen-containing heterocyclyl, etc.

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts

Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.

Lithium Bromide/Triethylamine Induced Cycloaddition of N-Alkylidene 2-Amino Esters and Amides to Electron-Deficient Olefins with High Regio- and Stereoselectivity

The imines of 2-amino esters and amides derived from glycine, alanine, and valine are deprotonated by the action of a lithium halide and triethylamine (or DBU).The resulting anionic intermediates undergo highly regio- and stereoselective cycloadditions with a variety of olefins activated by carbonyl-type substituents to produce stereochemically defined derivatives of proline esters or amides.The scope and limitations of this novel cycloaddition are discussed.