88254-07-3 Usage
General Description
The chemical 5,12-Naphthacenedione, 10-3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyloxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy- is a complex compound with a long name, commonly known as Daunorubicin. It is a chemotherapy medication used to treat certain types of cancer, including leukemia and lymphoma. Daunorubicin works by interfering with the growth and spread of cancer cells in the body. It belongs to a class of drugs known as anthracyclines and is commonly administered intravenously by a healthcare professional. It is considered an essential medicine by the World Health Organization and is included on the WHO Model List of Essential Medicines.
Check Digit Verification of cas no
The CAS Registry Mumber 88254-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,2,5 and 4 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88254-07:
(7*8)+(6*8)+(5*2)+(4*5)+(3*4)+(2*0)+(1*7)=153
153 % 10 = 3
So 88254-07-3 is a valid CAS Registry Number.
88254-07-3Relevant articles and documents
Intensely potent morpholinyl anthracyclines
Acton,Tong,Mosher,Wolgemuth
, p. 638 - 645 (2007/10/02)
3'-Deamino-3'-(3-cyano-4-morpholinyl)doxorubicin is a new analogue that is 100 to 1000 times more potent than doxorubicin against tumors in cell culture or in mice, that is active by intraperitoneal, intravenous, or oral dosing, and that does not produce chronic myocardial lesions in mice. This analogue was encountered in studies on the reductive alkylation of doxorubicin and daunorubicin with 2,2'-oxybis[acetaldehyde], which constructs a morpholino ring incorporating the amino N. The morpholinyl nitrile byproducts are separated by virtue of their nonbasicity from the expected morpholino derivatives. The 13-dihydro and 5-imino derivatives are also described in this important new class of anthracyclines.