88741-40-6

Basic information

• Product Name: Benzoyl chloride, 2-bromo-4-methoxy-
• CAS NO: 88741-40-6
• Molecular Formula: C8H6BrClO2
• Molecular Weight: 249.491
• Mol File: 88741-40-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzoyl chloride, 2-bromo-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-bromo-4-methoxy-(88741-40-6)
• EPA Substance Registry System: Benzoyl chloride, 2-bromo-4-methoxy-(88741-40-6)

Safety Data

• Hazardous Substances Data: 88741-40-6(Hazardous Substances Data)

Upstream product

• 74317-85-4 2-bromo-4-methoxybenzoic acid 
• 89691-67-8 1-(2-bromo-4-methoxyphenyl)ethanone 

Downstream Products

• 100009-74-3 N-(2',3',4'-trimethoxyphenethyl)-2-bromo-4-methoxybenzamide 
• 83287-07-4 N-(3',4',β-trimethoxyphenethyl)-2-bromo-4-methoxybenzamide 
• 127817-90-7 N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-brom-4-methoxybenzamid 
• 100009-78-7 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline 
• 100009-76-5 1-(2'-methoxycarbonyl-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline 
• 100009-80-1 1-(2'-bromo-4'-methoxyphenyl)-5,6,7-trimethoxy-3,4-dihydroisoquinoline 
• 100009-77-6 5-Methoxy-2-(5,6,7-trimethoxy-isoquinolin-1-yl)-benzoic acid 
• 83287-06-3 1-(2'-bromo-4'-methoxyphenyl)-6,7-dimethoxyisoquinoline 
• 83287-04-1 1-(2'-carboxy-4'-methoxyphenyl)-6,7-dimethoxyisoquinoline 
• 88741-65-5 methyl 2-(6,7-dimethoxyisoquinolin-1-yl)-5-methoxybenzoate 
• 83287-05-2 2-(6,7-dimethoxy-isoquinolin-1-yl)-5-methoxybenzonitrile 
• 127817-95-2 N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-brom-4-hydroxybenzamid 
• 1432371-67-9 2-bromo-N-cyclopropyl-4-methoxy-N-methylbenzamide 
• 666747-07-5 2-bromo-N,N-diisopropyl-4-methoxylbenzamide 

Relevant articles and documents

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1) removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can potentiate the cytotoxicity of TOP1 inhibitors and overcome cancer cell resistance to

Stereoinvertive C–C Bond Formation at the Boron-Bound Stereogenic Centers through Copper-Bipyridine-Catalyzed Intramolecular Coupling of α-Aminobenzylboronic Esters

Enantiospecific intramolecular Suzuki–Miyaura-type coupling with α-(2-halobenzoylamino)benzylboronic esters to give 3-substituted isoindolinones is achieved by using copper catalysts with 2,2′-bipyridine-based achiral ligands. Enantioenriched α-aminobenzylboron reactants bearing a hydrogen atom at the boron-bound stereogenic carbons undergo stereoinvertive coupling in the presence of a 6-phenyl-2,2′-bipyridine ligand with high enantiospecificity. α-Aminobenzylboronates bearing fully substituted boron-bound stereogenic centers also gave the 3,3-disubstituted isoindolinones with stereospecific stereochemical inversion in the presence of simple 2,2′-bipyridine as a ligand.

Palladium-Catalyzed Stereoselective Aza-Wacker-Heck Cyclization: One-Pot Stepwise Strategy toward Tetracyclic Fused Heterocycles

Palladium-catalyzed intramolecular tandem cyclization reactions were conducted for the synthesis of densely cis/cis-fused aza-tetracyclic structures. The process involved a palladium(II)-catalyzed aerobic aza-Wacker reaction, followed by a palladium(0)-catalyzed Heck reaction. The effects of the solvent and benzene substitution pattern on the one-pot, two-step cascade reaction were studied systematically, and a probable mechanism was proposed. Strained pentahydrobenzo[f]cyclopenta[hi]indolizin-6-one and racemic γ-lycorane can also be synthesized rapidly using this palladium-catalyzed aza-Wacker-Heck cyclization reaction.