83287-05-2

Upstream product

• 83287-06-3 1-(2'-bromo-4'-methoxyphenyl)-6,7-dimethoxyisoquinoline 
• 15462-83-6 6,7-dimethoxy-1-<(para-methoxy)phenyl>-3,4-dihydroisoquinoline 
• 15547-67-8 6,7-dimethoxy-1-(4-methoxy-phenyl)-isoquinoline 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 3424-93-9 4-methoxyphenylacetamide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 83287-07-4 N-(3',4',β-trimethoxyphenethyl)-2-bromo-4-methoxybenzamide 
• 544-92-3 copper(I) cyanide 
• 88741-40-6 2-Brom-4-methoxybenzoesaurechlorid 
• 4722-08-1 3,4-dimethoxy-β-methoxybenzeneethanamine 

Downstream Products

• 83287-02-9 menisporphine 
• 88741-65-5 methyl 2-(6,7-dimethoxyisoquinolin-1-yl)-5-methoxybenzoate 
• 83287-04-1 1-(2'-carboxy-4'-methoxyphenyl)-6,7-dimethoxyisoquinoline 

Relevant academic research and scientific papers

Ni-Catalyzed C-H Cyanation of (Hetero)arenes with 2-Cyanoisothiazolidine 1,1-Dioxide as a Cyanation Reagent

A nickel-catalyzed C-H cyanation reaction of arenes has been developed using 2-cyanoisothiazolidine 1,1-dioxide as an electrophilic cyanation reagent. Many different directing groups can be used in this cyanation to obtain a series of cyanation products with good yields. Adopting this strategy to introduce a cyano group, natural alkaloid menisporphine was successfully synthesized through cyano group conversion that further proved the practicality of this cyanation method.

Rhodium catalyzed cyanation of chelation assisted C-H bonds

A rhodium-catalyzed cyanation of chelation assisted C-H bonds is described employing N-cyano-N-phenyl-p-methylbenzenesulfonamide as an efficient cyanating reagent. The present method allowed the synthesis of various benzonitirle derivatives in good to excellent yield. A number of chelating groups are also effective in the present cyanation of C-H bonds. In addition, the developed methodology was applied in the formal synthesis of the isoquinoline alkaloid, menisporphine.

Chelation-assisted palladium-catalyzed direct cyanation of 2-arylpyridine C-H bonds

A chelation-assisted palladium-catalyzed ortho-cyanation of the sp 2 C-H bond by CuCN provided aromatic nitriles In moderate to good yields. Notably, the reaction could be conducted on a 10 mmol scale. The key Intermediate of the natural produc

STRUCTURE AND SYNTHESIS OF MENISPORPHINE, A NEW TYPE OF ISOQUINOLINE ALKALOID. ALKALOIDS OF MENISPERMUM DAURICUM DC. (9)

The structure of an unknown yellow base from Menispermum dauricum DC. (Menispermaceae) was determined to be 5,6,9-trimethoxy-7H-dibenzoquinolin-7-one from various spectral data and synthesis, and was named menisporphine.This is a new isoquinoline-ty