89380-14-3

Basic information

• Product Name: 2,4-Dichloro-5-methoxymethyl-pyrimidine
• Synonyms: 2,4-Dichloro-5-methoxymethyl-pyrimidine
• CAS NO: 89380-14-3
• Molecular Formula: C₆H₆Cl₂N₂O
• Molecular Weight: 193
• Mol File: 89380-14-3.mol

Chemical Properties

• Boiling Point: 258℃
• Flash Point: 110℃
• Appearance: /
• Density: 1.389
• CAS DataBase Reference: 2,4-Dichloro-5-methoxymethyl-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-5-methoxymethyl-pyrimidine(89380-14-3)
• EPA Substance Registry System: 2,4-Dichloro-5-methoxymethyl-pyrimidine(89380-14-3)

Safety Data

• Hazardous Substances Data: 89380-14-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-5-methoxymethyl-pyrimidine is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a versatile building block in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Dichloro-5-methoxymethyl-pyrimidine is utilized as a precursor in the production of herbicides and pesticides. Its incorporation into these products contributes to their effectiveness in controlling unwanted plant growth and protecting crops from pests, thereby enhancing agricultural productivity.
Used in Chemical Synthesis:
2,4-Dichloro-5-methoxymethyl-pyrimidine is employed as a synthetic intermediate for the creation of biologically active compounds. Its presence in the synthesis process is instrumental in developing new chemical entities with potential applications in various industries, including medicine, agriculture, and materials science.

Upstream product

• 124-41-4 sodium methylate 
• 7627-38-5 2,4-dichloro-5-(chloromethyl)pyrimidine 
• 4433-40-3 5-hydroxymethyl uracil 
• 57346-43-7 5-(methoxymethyl)pyrimidine-2,4-diol 
• 3590-48-5 5-(chloromethyl)pyrimidine-2,4-diol 

Relevant articles and documents

6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

A compound represented by Formula (I): wherein or the like Y1 is O or the like; Z1 is C(R4) or N; Z2a is C(R5a) or the like; Z3a is C(R6) or the like; R4, R5a and R6 are each independently a hydrogen atom or the like; R1 is substituted or unsubstituted aromatic carbocyclyl or the like; R2a, R2b, R2c and R2d are each independently a hydrogen atom or the like; X is N(R7a) or the like; R7a is a hydrogen atom or the like; R3 is or the like Ring B is a 6-membered aromatic carbocycle or the like; R9a and R10a are each independently halogen or the like; n is an integer from 1 to 5; m is an integer from 0 to 4; and p1 is an integer from 0 to 3, or a pharmaceutically acceptable salt thereof.

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

MONOCYCLIC PYRIMIDINE/PYRIDINE COMPOUNDS AS INHIBITORS OF P97 COMPLEX

Monocyclic pyrimidine and pyridine compounds having a benzyl amine substituent at the 4 position and a 5:6 bicyclic heteroaryl substituent at the 2 position of the pyrimidine or pyridine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.