57346-43-7Relevant academic research and scientific papers
MONOCYCLIC PYRIMIDINE/PYRIDINE COMPOUNDS AS INHIBITORS OF P97 COMPLEX
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Page/Page column 126, (2015/06/25)
Monocyclic pyrimidine and pyridine compounds having a benzyl amine substituent at the 4 position and a 5:6 bicyclic heteroaryl substituent at the 2 position of the pyrimidine or pyridine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.
Synthesis of various 5-alkoxymethyluracil analogues and structure-cytotoxic activity relationship study
Brulíková, Lucie,D?ubák, Petr,Hajdúch, Marián,Hlavá?, Jan
scheme or table, p. 2136 - 2144 (2011/11/06)
A number of 5-alkoxymethyluracil analogues were synthesized to evaluate their cytotoxic activity. 5-Alkoxymethyluracil derivatives 1 were prepared via known nucleophilic substitution of 5-chloromethyluracil 5 and subsequently transformed to their correspo
Anodic decarboxylative oxidation of carboxymethyluracil and -thymine isomers
Kaminski, Jaroslaw,Pachulska, Maria,Stolarski, Ryszard,Kazimierczuk, Zygmunt
, p. 2609 - 2616 (2007/10/03)
The anodic oxidative decarboxylation of isomers of uracil and thymine acetic acids was studied. Electrolysis in methanolic or ethanolic solutions yielded respective alkoxymethyl derivatives via carbocationic intermediates. In acetic acid/sodium acetate medium, these were trapped by acetate, resulting in corresponding acetoxymethyl derivatives. Electrolysis in fully deuterated methanol or deuterated acetic acid, allow to obtain respective trideuterated compounds.
