89781-52-2

Basic information

• Product Name: 8-OXO-5,6,7,8-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID
• Synonyms: 8-oxo-6,7-dihydro-5H-naphthalene-2-carboxylic acid;5,6,7,8-tetrahydro-8-oxo-2-Naphthalenecarboxylic acid
• CAS NO: 89781-52-2
• Molecular Formula: C11H10O3
• Molecular Weight: 190.2
• Mol File: 89781-52-2.mol

Chemical Properties

• Melting Point: 216 °C
• Boiling Point: 389.1±31.0 °C(Predicted)
• Appearance: /
• Density: 1.309±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.97±0.20(Predicted)
• CAS DataBase Reference: 8-OXO-5,6,7,8-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 8-OXO-5,6,7,8-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID(89781-52-2)
• EPA Substance Registry System: 8-OXO-5,6,7,8-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID(89781-52-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 89781-52-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-OXO-5,6,7,8-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID is used as a therapeutic agent for treating cancer and other Pin1-associated conditions. Its application is based on its ability to target and modulate the activity of Pin1, a peptidyl-prolyl isomerase enzyme that plays a crucial role in cell cycle regulation and has been implicated in the development and progression of various cancers. By inhibiting Pin1, this compound may help to prevent the growth and spread of cancer cells, offering a potential treatment option for patients with cancer and other Pin1-associated diseases.

Upstream product

• 124-38-9 carbon dioxide 
• 111773-13-8 7-Bromo-1,2,3,4-tetrahydronaphthalene-1-spiro-2'-(1',3'-dioxacyclopentane) 
• 100117-48-4 4-(4-acetylphenyl)butanoic acid 
• 71665-59-3 4-(4-acetylphenyl)butyric acid ethyl ester 
• 10031-93-3 ethyl 4-phenylbutyrate 
• 34162-06-6 4-(3-carboxypropyl)benzoic acid 

Downstream Products

• 89781-55-5 5,6-dihydro-7-(1H-imidazol-1-yl)-2-naphthalenecarboxylic acid 
• 40353-34-2 7-nitro-3,4-dihydro-2H-naphthalen-1-one 
• 116047-26-8 methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate 
• 152769-09-0 Boc-(R)-Amhn-Lys(Z)-Gly-OMe 

Relevant articles and documents

Diastereoselective. synergistic dual-mode optical switch with integrated chirochromic helicene and photochromic bis-azobenzene moieties

(Figure Presented) An unprecedented dual-mode optical switch by combining helicene and bis-azobenzene moieties in proximity allows for cooperative, highly diastereoselective chlrochromic (92/8 to 3/97) and photochromic (>99/1 to 19/81) switchings both in

Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders

This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.

Three novel mimics for the construction of sterically constrained protein turn models

8-Amino-5,6,7,8-tetrahydro-2-naphthoic acid (1), 8-aminomethyl-5,6,7,8-tetrahydro-2-naphthoic acid (2), and 8-aminomethyl-2-naphthoic acid (3) were synthesized in their protected forms for use in the construction of sterically constrained protein turn models.