89942-18-7

Basic information

• Product Name: 1,3-Dioxolane, 4-(2-bromoethyl)-2,2-dimethyl-
• Synonyms: isopropylidene ketal of rac-3,4-dihydroxybutyl bromide;4-Brom-1,2-O-isopropyliden-butan
• CAS NO: 89942-18-7
• Molecular Formula: C7H13BrO2
• Molecular Weight: 209.08100
• Mol File: 89942-18-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 4-(2-bromoethyl)-2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 4-(2-bromoethyl)-2,2-dimethyl-(89942-18-7)
• EPA Substance Registry System: 1,3-Dioxolane, 4-(2-bromoethyl)-2,2-dimethyl-(89942-18-7)

Safety Data

• Hazardous Substances Data: 89942-18-7(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Slightly sweet

Uses

a. Solvent
b. Production of pharmaceuticals
c. Production of agricultural chemicals
d. Synthesis of organic compounds (perfumes, flavoring agents)

Chemical classification

Alkyl halide

Reactivity

Bromine atom makes it reactive in various chemical reactions

Safety precautions

a. Flammable
b. Potential skin and eye irritant
c. Handle with caution

Upstream product

• 76099-47-3 rac-O-isopropylidene-3,4-dihydroxybutyl methanesulfonate 
• 5754-34-7 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 
• 33835-83-5 rac-3,4-dihydroxybutyl bromide 
• 67-64-1 acetone 

Downstream Products

• 33835-83-5 rac-3,4-dihydroxybutyl bromide 

Relevant articles and documents

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5-and 3′-position have been extensively investigated, but the impact of substituents in 5′-position is not equally well-studied. Here, we report the synthesis of new indirubin 3′-and 5′-derivatives in the search of water-soluble indirubins by introducing basic centers. Antiproliferative activity of all compounds in tumor cells was evaluated along with kinase inhibition of selected compounds. The results show the 3′-position to tolerate large substituents without compromising activity, whereas bulk and rigid substituents in 5′-position appear unfavorable. Screening molecular targets of water-soluble 3′-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells. Consistently, 6ha inhibited tumor cell growth in the NCI 60 cell line panel and induced apoptosis. The results indicate that the 5′-position provides limited space for chemical modifications and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.

COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B

The present invention provides compositions and methods for the delivery of interfering RNAs that silence APOB expression to liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

rac-3,4-DIHYDROXYBUTYLARSONIC ACID: A KEY INTERMEDIATE FOR ISOSTERIC ARSONOLIPIDS

Synthetic routes starting from 4-bromobut-1-ene and leading to rac-dihydroxybutylarsonic acid and diphenyl rac-3,4-dihydroxybutyldithioarsonite were explored.All of them gave overall yields 5-16percent.Some properties of the free acid and its dilithium salt are described. Key words: Arsonic acids, (diethylamino)chlorarsine, the Mayer reaction,salts of arsonic acids, cyclization of arsonic acids.