33835-83-5

Basic information

• Product Name: 4-broMobutane-1,2-diol
• Synonyms: 4-broMobutane-1,2-diol;4-bromo-1,2-Butanediol
• CAS NO: 33835-83-5
• Molecular Formula: C₄H₉BrO₂
• Molecular Weight: 169.01706
• EINECS: -0
• Mol File: 33835-83-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 288.8°Cat760mmHg
• Flash Point: 128.5°C
• Appearance: /
• Density: 1.638g/cm³
• Vapor Pressure: 0.000253mmHg at 25°C
• Refractive Index: 1.519
• PKA: 13.91±0.20(Predicted)
• CAS DataBase Reference: 4-broMobutane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMobutane-1,2-diol(33835-83-5)
• EPA Substance Registry System: 4-broMobutane-1,2-diol(33835-83-5)

Safety Data

• Hazardous Substances Data: 33835-83-5(Hazardous Substances Data)

Usage

General Description

4-Bromobutane-1,2-diol is a chemical compound with the molecular formula C4H9BrO2. This organic compound consists of a four-carbon alkane chain where one hydrogen atom replaced by a bromine atom, and two of the other carbon atoms are connected to hydroxyl (OH) groups, making it a diol. 4-broMobutane-1,2-diol falls within the broader category of organic chemicals known as halohydrins, which are compounds that contain both a halogen (in this case, bromine) and a hydroxyl group. The properties and reactivity of 4-Bromobutane-1,2-diol would generally be influenced by the presence of these functional groups. Applications or uses of this specific compound are not extensively documented, likely implying it’s typically utilized as an intermediate or a reactant within broader chemical synthesis processes.

InChI:InChI=1/C4H9BrO2/c5-2-1-4(7)3-6/h4,6-7H,1-3H2

Upstream product

• 89942-18-7 isopropylidene ketal of rac-3,4-dihydroxybutyl bromide 
• 5162-44-7 1-bromo-4-butene 
• 64-18-6 formic acid 

Downstream Products

• 3068-00-6 D,L-1,2,4-butanetriol 
• 89942-18-7 isopropylidene ketal of rac-3,4-dihydroxybutyl bromide 
• 453-20-3 3-Hydroxytetrahydrofuran 

Relevant articles and documents

IMPROVED CATIONIC LIPIDS AND METHODS FOR THE DELIVERY OF THERAPEUTIC AGENTS

The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION

The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene expression and methods of using such compositions to silence EBOV gene expression. More particularly, the invention provides unmodified and chemically modified interfering RNA which silence EBOV gene expression and methods of use thereof, e.g., for preventing or treating EBOV infections caused by one or more EBOV species such as Zaire EBOV. The invention also provides serum-stable nucleic acid-lipid particles comprising one or more interfering RNA molecules, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. Methods of silencing EBOV gene expression by administering one or more interfering RNA molecules to a mammalian subject are also provided.

rac-3,4-DIHYDROXYBUTYLARSONIC ACID: A KEY INTERMEDIATE FOR ISOSTERIC ARSONOLIPIDS

Synthetic routes starting from 4-bromobut-1-ene and leading to rac-dihydroxybutylarsonic acid and diphenyl rac-3,4-dihydroxybutyldithioarsonite were explored.All of them gave overall yields 5-16percent.Some properties of the free acid and its dilithium salt are described. Key words: Arsonic acids, (diethylamino)chlorarsine, the Mayer reaction,salts of arsonic acids, cyclization of arsonic acids.