33835-83-5

Usage

Uses

Used in Chemical Synthesis:
4-Bromobutane-1,2-diol is used as an intermediate or reactant in various chemical synthesis processes. Its unique structure with a bromine atom and hydroxyl groups allows it to participate in a range of reactions, making it a valuable component in the production of more complex molecules.
Used in Pharmaceutical Industry:
Although not extensively documented, 4-Bromobutane-1,2-diol may be utilized in the pharmaceutical industry as a building block for the synthesis of drug molecules. Its reactivity and functional groups can be harnessed to create compounds with potential therapeutic applications.
Used in Material Science:
4-Bromobutane-1,2-diol could also find applications in material science, particularly in the development of new materials with specific properties. Its chemical structure may contribute to the formation of polymers or other materials with unique characteristics, such as improved stability or reactivity.
Used in Research and Development:
4-Bromobutane-1,2-diol may be employed in research and development settings to explore its chemical properties and potential applications. Scientists and researchers can use 4-broMobutane-1,2-diol to study reaction mechanisms, investigate its interactions with other molecules, and develop new synthetic methods.

InChI:InChI=1/C4H9BrO2/c5-2-1-4(7)3-6/h4,6-7H,1-3H2

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 64-18-6 formic acid 
• 89942-18-7 isopropylidene ketal of rac-3,4-dihydroxybutyl bromide 

Downstream Products

• 453-20-3 3-Hydroxytetrahydrofuran 
• 3068-00-6 D,L-1,2,4-butanetriol 
• 89942-18-7 isopropylidene ketal of rac-3,4-dihydroxybutyl bromide 

Relevant academic research and scientific papers

IMPROVED CATIONIC LIPIDS AND METHODS FOR THE DELIVERY OF THERAPEUTIC AGENTS

The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B

The present invention provides compositions and methods for the delivery of interfering RNAs that silence APOB expression to liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION

The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene expression and methods of using such compositions to silence EBOV gene expression. More particularly, the invention provides unmodified and chemically modified interfering RNA which silence EBOV gene expression and methods of use thereof, e.g., for preventing or treating EBOV infections caused by one or more EBOV species such as Zaire EBOV. The invention also provides serum-stable nucleic acid-lipid particles comprising one or more interfering RNA molecules, a cationic lipid, and a non-cationic lipid, which can further comprise a conjugated lipid that inhibits aggregation of particles. Methods of silencing EBOV gene expression by administering one or more interfering RNA molecules to a mammalian subject are also provided.

USES AND COMPOSITIONS OF NITRATE ESTERS FOR PROVIDING SEDATION

Use of certain nitrate ester compounds or pharmaceutically acceptable salts thereof in the manufacture of a medicament for treating pain or providing analgesia.

rac-3,4-DIHYDROXYBUTYLARSONIC ACID: A KEY INTERMEDIATE FOR ISOSTERIC ARSONOLIPIDS

Synthetic routes starting from 4-bromobut-1-ene and leading to rac-dihydroxybutylarsonic acid and diphenyl rac-3,4-dihydroxybutyldithioarsonite were explored.All of them gave overall yields 5-16percent.Some properties of the free acid and its dilithium salt are described. Key words: Arsonic acids, (diethylamino)chlorarsine, the Mayer reaction,salts of arsonic acids, cyclization of arsonic acids.