90610-69-8

Basic information

• Product Name: 3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID
• Synonyms: ASISCHEM A98433;3-(4-(AMINOSULFONYL)PHENYL)PROPANOIC ACID;3-[4-(AMINOSULPHONYL)PHENYL]PROPANOIC ACID;4-(AMINOSULPHONYL)DIHYDROCINNAMIC ACID;3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID;TIMTEC-BB SBB011591;P-AMINOSULFONYLDIHYDROCINNAMIC ACID;4-(Aminosulphonyl)dihydrocinnamic acid 95%
• CAS NO: 90610-69-8
• Molecular Formula: C₉H₁₁NO₄S
• Molecular Weight: 229.25
• Product Categories: blocks;Carboxes;Sulfonamides
• Mol File: 90610-69-8.mol

Chemical Properties

• Melting Point: 164-166
• Boiling Point: 459 °C at 760 mmHg
• Flash Point: 231.4 °C
• Appearance: /
• Density: 1.412 g/cm³
• Vapor Pressure: 3.2E-09mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID(90610-69-8)
• EPA Substance Registry System: 3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID(90610-69-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 90610-69-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID is used as an anti-inflammatory and analgesic agent for the treatment of conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Its application is based on its ability to reduce inflammation and alleviate pain associated with these diseases.
Used in Oncology:
In the field of oncology, 3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID is used for its potential chemopreventive effects, particularly in the prevention of colorectal cancer. Its application in this context is due to its capacity to modulate cellular processes that may contribute to the development of cancer.
However, it is important to note that the use of 3-(4-SULFAMOYL-PHENYL)-PROPIONIC ACID is associated with potential side effects, including gastrointestinal irritation, peptic ulcers, and liver toxicity. Therefore, it should be used with caution, especially in patients with a history of these conditions.

InChI:InChI=1/C9H11NO4S/c10-15(13,14)8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5H,3,6H2,(H,11,12)(H2,10,13,14)

Upstream product

• 147723-92-0 4-sulfamoyl-trans-cinnamic acid 
• 2633-64-9 4-vinylbenzenesulfonamide 
• 590-29-4 potassium formate 
• 501-52-0 3-Phenylpropionic acid 
• 79-10-7 acrylic acid 

Downstream Products

• 1312798-64-3 C₂₃H₂₆N₂O₁₀S 
• 134672-93-8 p-aminosulfonyldihydrocinnamic acid ethyl ester 
• 35303-76-5 4-(2-aminoethyl)benzenesulfonamide 

Relevant articles and documents

Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate across Activated Alkenes

Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across diverse functionalized alkene substrates with excellent regioselectivity. This operationally simple procedure can be readily scaled in batch at low photocatalyst loading (0.01% photocatalyst). Furthermore, this new reaction can leverage commercially available formate carbon isotologues to enable the direct synthesis of isotopically labeled carboxylic acids. Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2?- as a key reactive intermediate.

Effective Access to Multivalent Inhibitors of Carbonic Anhydrases Promoted by Peptide Bioconjugation

Multivalency has impressive effects on (bio)molecular recognition, through the simultaneous presentation of multiple copies of a ligand, which can change a weak millimolar binder into a potent nanomolar one. The implementation of multivalency in enzyme inhibition is rather recent, being exemplified by few serendipitous discoveries, and hitherto relying on the random exploration of new multivalent structures as potential enzyme inhibitors. Here, a straightforward and versatile method is reported that enables the construction of multivalent systems for the inhibition of carbonic anhydrases (CA), widespread enzymes that catalyze a fundamental biochemical reaction. Oxime and hydrazone click-type bioconjugation techniques were successfully used for the preparation of tetravalent peptide conjugates tethered with sulfonamide CA inhibitors. The enzyme inhibition assays show that multivalent effects were present with these novel compounds, but also reveal various structural effects provided by the scaffolds. The versatility of this approach may facilitate the exploration of structure–activity relationships for other types of enzyme inhibitors.