910209-21-1

Basic information

• Product Name: CYCLOPROPANESULFINIC ACID, SODIUM SALT
• Synonyms: CYCLOPROPANESULFINIC ACID, SODIUM SALT;Sodium Cyclopropanesulfinate
• CAS NO: 910209-21-1
• Molecular Formula: C₃H₅O₂S*Na
• Molecular Weight: 128.13
• Mol File: 910209-21-1.mol

Chemical Properties

• Melting Point: 245-248°C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: CYCLOPROPANESULFINIC ACID, SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPROPANESULFINIC ACID, SODIUM SALT(910209-21-1)
• EPA Substance Registry System: CYCLOPROPANESULFINIC ACID, SODIUM SALT(910209-21-1)

Safety Data

• Hazardous Substances Data: 910209-21-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cyclopropanesulfinic acid, sodium salt is used as a chemical reagent for the synthesis of AMG 232 (A576560), a potent MDM2-P53 inhibitor. Cyclopropanesulfinic acid, sodium salt has potential applications as an anti-tumor agent, making it valuable in the development of cancer treatments.

InChI:InChI=1/C3H6O2S.Na/c4-6(5)3-1-2-3;/h3H,1-2H2,(H,4,5);/q;+1/p-1

Upstream product

• 139631-62-2 cyclopropanesulfonyl chloride 

Downstream Products

• 1147558-09-5 C₉H₁₀FNO₂S 
• 1196875-94-1 4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-b]pyridine 
• 1196875-80-5 methyl 3-((1R)-3-(benzyloxy)cyclopentyl)-2-(4-(cyclopropylsulfonyl)-1H-indazol-1-yl)propanoate 
• 1403988-73-7 1-[(cyclopropylsulfonyl)methyl]-3-nitrobenzene 
• 1416364-90-3 2-{4-[(1R,2R)-2-({[4-(cyclopropylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidin-1-y}-5-ethylpyrimidine 
• 1097921-71-5 1-(cyclopropylsulfonyl)-2-nitrobenzene 
• 19433-06-8 cyclopropyl 4-methoxyphenyl sulphone 
• 928219-10-7 cyclopropyl(o-tolyl)sulfane 
• 1147558-13-1 4-(cyclopropylsulfonyl)aniline 

Relevant articles and documents

Visible-Light-Induced, Palladium-Catalyzed 1,4-Difunctionalization of 1,3-Dienes with Bromodifluoroacetamides

A highly modular 1,4-difunctionalization of 1,3-dienes with bromodifluoroacetamides and sulfinates/amines through a photoinduced palladium-catalyzed radical relay process is described herein. This developed protocol offers a facile and general route to ac

Electrochemical-Induced Hydroxysulfonylation of α-CF3 Alkenes to Access Tertiary β-Hydroxysulfones

An electrochemical hydroxysulfonylation of α-CF3 alkenes was accomplished in this work. By using easily available sodium sulfinates as the sulfonylating agents, a series of valuable α-trifluoromethyl tertiary alcohols were synthesized under mild and environmentally friendly electrolysis conditions in moderate to good yields. The preliminary mechanistic investigation indicates that this difunctional reaction involves a radical process via a sulfonyl radical. Gram-scale synthesis shows the significant potential application of this protocol. (Figure presented.).

Electrochemistry Enabled Nickel-Catalyzed Selective C?S Bond Coupling Reaction

This work describes an electrochemical enabled nickel-catalyzed chemoselective C?S bond coupling protocol for the production of aryl sulfides and sulfones. By simply switching the nickel catalysts and electrodes, this electrochemical C?S bond coupling has demonstrated excellent redox activity, scalability and sustainability. Furthermore, the mechanism for this electrochemical cross-coupling reaction has been investigated.

Synthesis of β-Keto Sulfones by Oxy-Sulfonylation of Alkynes in HFIP

Herein, we have established a method for the construction of β-keto sulfones through aerobic oxy-sulfonylation of alkynes with sulfinates. The reaction performed employing air as the oxidant and oxygen source. Moreover, this protocol exhibits low consume of sulfinates, short reaction period, and minimal waste. Mechanism study and density functional theory (DFT) calculation showed that the solvent played a significant role in the transformation. (Figure presented.).

Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol

Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant molecules. In the presence of D2O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy.

Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts

We herein report a selective and catalytic C(sp3)-H functionalization approach to access amines bearing organo-sulfonyl and organo-thiol groups. This reaction proceeds through a cascade process of N-radical formation, alkyl radical formation via 1,5-HAT, and C-S bond formation, thereby offering a series of functionalized amines. This method could enable primary, secondary, and tertiary C(sp3)-H sulfonylation and thiolation and also exhibits good functional group tolerance.

Electrochemical Radical-Radical Cross-Coupling Approach between Sodium Sulfinates and 2 H-Indazoles to 3-Sulfonylated 2 H-Indazoles

A direct cross-coupling between sodium sulfinates and 2H-indazoles has been developed under electrochemical conditions. The utilization of a graphite anode and platinum cathode in an undivided cell with a constant current of 7 mA allowed the concurrent oxidations of sulfinates and 2H-indazoles to sulfonyl radical and radical cationic 2H-indazoles, facilitating the direct radical-radical coupling strategy to 3-sulfonylated 2H-indazole derivatives. The transition-metal- A nd redox-reagent-free synthetic approach should serve as a valuable synthetic tool to achieve heteroaromatic compounds.

ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS

The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Sulfonyl pyridine amide derivatives and preparation method thereof

The invention relates to a Sulfonyl pyridine amide derivatives and a preparation method thereof; the preparation method comprises the following steps: adding a compound as shown in a structural formula (II), a compound as shown in a structural formula (III), an oxidant, an additive and a heterogeneous biomass supported copper catalyst into a reaction container, adding a solvent, and carrying out astirring reaction at room temperature; and after the reaction is finished, filtering, extracting, concentrating, separating and purifying to obtain the sulfonyl pyridine amide derivative with the structural formula shown in the formula (I). The synthesis method of the sulfonyl pyridine amide derivatives is scientific and reasonable, and a series of sulfonyl pyridine amide derivatives are synthesized by a green and efficient synthesis method by adopting a heterogeneous biomass copper-loaded catalyst for catalytic reaction.

Hydrosulfonylation of Unactivated Alkenes by Visible Light Photoredox Catalysis

The anti-Markovnikov hydrosulfonylation of unactivated alkenes with sodium sulfinates was realized via [Ir(dF(CF3)ppy)2(dtbbpy)]PF6-mediated visible light photoredox catalysis. The presence of an acid such as acetic acid is essential for the reaction to take place. A variety of unactivated alkenes can be transformed into sulfones with good yield and high regioselectivity using this reaction, which is proposed to proceed by a radical mechanism.