911466-96-1

Basic information

• Product Name: 2,4-Thiazoledicarboxylic acid,2-ethyl ester
• Synonyms: 2,4-Thiazoledicarboxylic acid,2-ethyl ester;2-(Ethoxycarbonyl)thiazole-4-carboxylic acid;2-(Ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid
• CAS NO: 911466-96-1
• Molecular Formula: C₇H₇NO₄S
• Molecular Weight: 201.2
• Mol File: 911466-96-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 373.5±34.0 °C(Predicted)
• Appearance: /
• Density: 1.446
• Storage Temp.: 2-8°C
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 2,4-Thiazoledicarboxylic acid,2-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Thiazoledicarboxylic acid,2-ethyl ester(911466-96-1)
• EPA Substance Registry System: 2,4-Thiazoledicarboxylic acid,2-ethyl ester(911466-96-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 911466-96-1(Hazardous Substances Data)

Usage

General Description

2,4-Thiazoledicarboxylic acid, 2-ethyl ester is a chemical compound with the molecular formula C6H7NO2S. It is a colorless to light yellow liquid with a pungent odor, and it is commonly used as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals. 2,4-Thiazoledicarboxylic acid,2-ethyl ester is also known for its use as a chemical intermediate in the production of dyes, pigments, and other organic compounds. It is important to handle this chemical with care as it may cause skin and eye irritation upon contact, and it should be stored and disposed of properly according to safety regulations.

Upstream product

• 928716-12-5 ethyl thiooxamate 
• 1113-59-3 bromopyruvic acid 
• 40235-67-4 diethyl thiazole-2,4-dicarboxylate 
• 16982-21-1 ethyl 2-amino-2-thioxoacetate 

Downstream Products

• 1023594-54-8 4-tert-butyl 2-ethyl thiazole-2,4-dicarboxylate 
• 1029432-03-8 4-(tert-butoxycarbonyl)thiazole-2-carboxylic acid 

Relevant articles and documents

ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C

A method of treating cancer comprises administering: (a) a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof; and (b) a therapeutically effective amount of an additional anti-cancer agent, to a subject in need of such treatment, the compound of Formula (I) being: where X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this disclosure.

METHODS OF TREATING CANCER

The present disclosure relates to methods of treating cancer in a patient using a combination of an inhibitor of an immune checkpoint protein and an indole compound or its phosphate derivative.

NOVEL FERROPORTIN INHIBITORS

The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.