912286-42-1

Basic information

• Product Name: 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide
• Synonyms: 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide
• CAS NO: 912286-42-1
• Molecular Weight: 481.594
• Mol File: 912286-42-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide(912286-42-1)
• EPA Substance Registry System: 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-propionamide(912286-42-1)

Safety Data

• Hazardous Substances Data: 912286-42-1(Hazardous Substances Data)

Upstream product

• 3339-73-9 3-phthalimidopropanoic acid 
• 17137-11-0 3-phthalimidopropionyl chloride 
• 21409-26-7 (1-Phenethyl-piperidin-4-yl)-phenyl-amine 

Downstream Products

• 912286-47-6 2-amino-N-[(1-{2-[(1-phenethyl-piperidin-4-yl)-phenyl-carbamoyl]-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-propionamide 
• 912286-46-5 2-(2-amino-acetylamino)-N-{2-[(1-phenethyl-piperidin-4-yl)-phenyl-carbamoyl]-ethyl}-3-phenyl-propionamide 
• 912286-43-2 2-amino-N-{2-[(1-phenethyl-piperidin-4-yl)-phenyl-carbamoyl]-ethyl}-3-phenyl-propionamide 

Relevant articles and documents

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity

An enkephalin analogue coupled to 'aminofentanyl' has been synthesized and tested for biological activities at the μ and δ opioid receptors. Aminofentanyl which represents a structural derivative of fentanyl has been synthesized by acylation of 1-(2-phenethyl)-4-(N-anilino)piperidine with phthaloyl protected β-alaninyl chloride in the presence of DIPEA, followed by deprotection with hydrazine hydrate. Aminofentanyl has also been successfully acylated with ethyl isocyanate, various acid anhydrides, to further investigate structure-activity relationships of these new fentanyl derivatives. Among the new derivatives compound 7 which carries a Tyr-d-Ala-Gly-Phe opioid message sequence showed good opioid affinity (1 nM at both δ and μ opioid receptors) and bioactivity (34.9 nM in MVD and 42 nM in GPI/LMMP bioassays).