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936366-46-0

{(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester

    Cas No: 936366-46-0

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  • 936366-46-0 Structure

  • Basic information

    1. Product Name: {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester
    2. Synonyms: {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester
    3. CAS NO:936366-46-0
    4. Molecular Formula:
    5. Molecular Weight: 469.876
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 936366-46-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester(936366-46-0)
    11. EPA Substance Registry System: {(5-chlorobenzo[b]thiophen-3-yl)[2-(3,4-difluorophenyl)vinylcarbamoyl]methyl}-methylphosphinic acid ethyl ester(936366-46-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 936366-46-0(Hazardous Substances Data)

936366-46-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 936366-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,6,3,6 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 936366-46:
(8*9)+(7*3)+(6*6)+(5*3)+(4*6)+(3*6)+(2*4)+(1*6)=200
200 % 10 = 0
So 936366-46-0 is a valid CAS Registry Number.

936366-46-0Relevant articles and documents

PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS

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Page/Page column 145-146, (2010/05/14)

The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders.

Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase

Greco, Michael N.,Hawkins, Michael J.,Powell, Eugene T.,Almond Jr., Harold R.,De Garavilla, Lawrence,Hall, Jeffrey,Minor, Lisa K.,Wang, Yuanping,Corcoran, Thomas W.,Di Cera, Enrico,Cantwell, Angelene M.,Savvides, Savvas N.,Damiano, Bruce P.,Maryanoff, Bruce E.

, p. 1727 - 1730 (2008/02/02)

A series of β-carboxamido-phosphon(in)ic acids (2) was identified as a new structural motif for obtaining potent inhibitors of human mast cell chymase. For example, 1-naphthyl derivative 5f had an IC50 value of 29 nM and (E)-styryl derivative 6

Novel inhibitors of chymase

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Page/Page column 50, (2008/06/13)

The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

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