96254-05-6

Basic information

• Product Name: 2-(TRIFLUOROACETOXY)PYRIDINE
• Synonyms: 2-PYRIDYL TRIFLUOROACETATE;2-(TRIFLUOROACETOXY)PYRIDINE;2-(TRIFLUOROACETOXY)PYRIDINE 98%
• CAS NO: 96254-05-6
• Molecular Formula: C₇H₄F₃NO₂
• Molecular Weight: 191.11
• Product Categories: Heterocyclic Compounds;Building Blocks;C7 to C8;Chemical Synthesis;Heterocyclic Building Blocks;Pyridines
• Mol File: 96254-05-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 60 °C0.3 mm Hg(lit.)
• Flash Point: 120 °F
• Appearance: /
• Density: 1.356 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.45mmHg at 25°C
• Refractive Index: n20/D 1.421(lit.)
• Storage Temp.: 2-8°C
• BRN: 3607316
• CAS DataBase Reference: 2-(TRIFLUOROACETOXY)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROACETOXY)PYRIDINE(96254-05-6)
• EPA Substance Registry System: 2-(TRIFLUOROACETOXY)PYRIDINE(96254-05-6)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• F: 8-10-21
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 96254-05-6(Hazardous Substances Data)

Usage

Description

2-(TRIFLUOROACETOXY)PYRIDINE, with the molecular formula C7H4F3NO2, is a pyridine derivative featuring a trifluoroacetoxy group at the 2-position of the pyridine ring. 2-(TRIFLUOROACETOXY)PYRIDINE is recognized for its versatility in organic synthesis, enabling a range of chemical reactions such as nucleophilic substitution, oxidation, and reduction.

Uses

Used in Pharmaceutical Industry:
2-(TRIFLUOROACETOXY)PYRIDINE is used as a building block in the synthesis of various active pharmaceutical ingredients and intermediates. Its unique chemical properties allow for the creation of novel compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(TRIFLUOROACETOXY)PYRIDINE serves as a key component in the development of new agrochemicals, contributing to the production of effective and innovative products for crop protection and other agricultural applications.
Used in Medicinal Chemistry Research:
2-(TRIFLUOROACETOXY)PYRIDINE is also utilized in medicinal chemistry research, where its potential biological activities are explored. This research aims to uncover new avenues for drug discovery and the improvement of existing therapeutic agents.

InChI:InChI=1/C7H4F3NO2/c8-7(9,10)6(12)13-5-3-1-2-4-11-5/h1-4H

Upstream product

• 142-08-5 2-hydroxypyridin 
• 407-25-0 trifluoroacetic anhydride 
• 142-08-5 2-Pyridone 

Downstream Products

• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 
• 338959-40-3 1-benzyl-2,3-dihydro-8-(4-trifluoroacetylpiperazin-1-yl)pyrrolo[3,2-g]isoquinoline 
• 287970-98-3 N-(2,6-diisopropyl-phenyl)-2,2,2-trifluoro-acetamide 
• 500-73-2 phenyl trifluoroacetate 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 1549-45-7 cyclohexyl trifluoroacetate 
• 351-70-2 benzyl trifluoroacetate 
• 144181-67-9 N-(4-chloro-2-hydroxyphenyl)-2,2,2-trifluoroacetamide 
• 394-59-2 2,2,2-trifluoro-1-(p-tolyl)ethanone 
• 10595-66-1 2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 16184-87-5 2,2,2-trifluoro-1-(2,4-dimethylphenyl)ethanone 
• 340-11-4 2,2,2-trifluoro-N,N-diphenylacetamide 
• 404-27-3 2,2,2-trifluoro-N-(4-nitrophenyl)acetamide 

Relevant articles and documents

2-(Trifluoroacetyloxy)pyridine as a Mild Trifluoroacetylating Reagent of Amines and Alcohols

A new trifluoroacetylating reagent, 2-(trifluoroacetyloxy)pyridine (TFAP), was prepared by the reaction of 2-pyridinol and trifluoroacetic anhydride.TFAP has been found to be effective in the trifluoroacetylation of aliphatic and aromatic amines and alcohols including phenol under mild conditions.The reaction of p-nitrophenol with TFAP in ether gave the hydrogen-bonded complex between the phenol and 2-pyridone.This reagent has also been shown to be useful for the intramolecular dehydration of aldehyde oximes and amides to give nitriles in high yields.