10595-66-1

Basic information

• Product Name: AcetaMide, 2,2,2-trifluoro-N-(2-hydroxyphenyl)-
• Synonyms: AcetaMide, 2,2,2-trifluoro-N-(2-hydroxyphenyl)-
• CAS NO: 10595-66-1
• Molecular Formula: C₈H₆F₃NO₂
• Molecular Weight: 205.1339496
• Mol File: 10595-66-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AcetaMide, 2,2,2-trifluoro-N-(2-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, 2,2,2-trifluoro-N-(2-hydroxyphenyl)-(10595-66-1)
• EPA Substance Registry System: AcetaMide, 2,2,2-trifluoro-N-(2-hydroxyphenyl)-(10595-66-1)

Safety Data

• Hazardous Substances Data: 10595-66-1(Hazardous Substances Data)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 76-05-1 trifluoroacetic acid 
• 773-29-5 trans/cis-octafluoro-2,3-epoxybutane 
• 95-55-6 2-amino-phenol 
• 622-37-7 Phenyl azide 
• 4846-21-3 O-phenylhydroxylamine 
• 407-25-0 trifluoroacetic anhydride 
• 96254-05-6 2-(trifluoroacetyloxy)pyridine 
• 6832-98-0 palmitanilide 
• 103-84-4 Acetanilid 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 62-53-3 aniline 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 54535-22-7 diethyl (anilinomethylene)malonate 

Downstream Products

• 837370-60-2 [Fe(2,3,7,8,12,13,17,18-octaethyl-21H,23H-porphyrinato)(2-trifluoroacetylaminophenolato)] 
• 307003-22-1 O-benzyl-2-trifluoroacetamido-4-(1,2-dideoxy-3,5-O-ditoluoyl-β-D-ribofuranos-1-yl)-phenol 
• 307003-23-2 O-benzyl-2-trifluoroacetamido-4-(1,2-dideoxy-β-D-ribofuranos-1-yl)-phenol 
• 355114-86-2 O-benzyl-2-amino-4-(1,2-dideoxy-β-D-ribofuranos-1-yl)-phenol 
• 144879-42-5 O-benzyl-2-trifluoroacetamidophenol 

Relevant articles and documents

A Smart Latent Catalyst Containing o-Trifluoroacetamide Functional Benzoxazine: Precursor for Low Temperature Formation of Very High Performance Polybenzoxazole with Low Dielectric Constant and High Thermal Stability

A novel difunctional benzoxazine with o-trifluoroacetamide functionality has been synthesized via Mannich condensation. The chemical structure of synthesized monomer has also been confirmed by 1H, 13C, and 19F nuclear magn

Metal-free chemoselective ortho -C(sp2)-F bond hydroxylation and N-trifluoroacylation of fluoroarylamines for domino synthesis of 2-(N-trifluoroacyl)aminophenols

Abstract A novel chemoselective reaction for the formation of C-O bonds by C(sp2)-F bond cleavage and concomitant N-trifluoroacylation of fluoroanilines using trifluoroacetic acid and Oxone is presented. This domino reaction gives o-hydroxy-N-trifluoroacetanilides in good yields under metal-free conditions in a single step. Selective ortho-directed monohydroxylation and N-trifluoroacylation of 2- and 6-fluoro- or 2,6-difluoro-substituted anilines takes place in this transformation.

Pd-catalyzed sp2 C-H hydroxylation with TFA/TFAA via weak coordinations

An efficient sp2 C-H hydroxylation has been developed for the synthesis of a wide range of functionalized phenols with aryl ketones, benzoates, benzamides, acetanilides and sulfonamides through palladium(II) catalysis. A trifluoroacetic acid (TFA)/trifluoroacetic anhydride (TFAA) co-solvent system serves as the oxygen source and is the critical factor for weak coordination promoted C-H activation. Georg Thieme Verlag Stuttgart New York.