96546-77-9

Basic information

• Product Name: 5-bromo-1-(p-toluenesulfonyl)-1H-indole
• Synonyms: 5-bromo-1-(p-toluenesulfonyl)-1H-indole;5-Bromo-1-[(4-methylphenyl)sulfonyl]-1H-indole
• CAS NO: 96546-77-9
• Molecular Formula: C₁₅H₁₂BrNO₂S
• Molecular Weight: 350
• Mol File: 96546-77-9.mol
• Article Data: 38

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-bromo-1-(p-toluenesulfonyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1-(p-toluenesulfonyl)-1H-indole(96546-77-9)
• EPA Substance Registry System: 5-bromo-1-(p-toluenesulfonyl)-1H-indole(96546-77-9)

Safety Data

• Hazardous Substances Data: 96546-77-9(Hazardous Substances Data)

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 26807-68-1 indolin-2-sulfonic acid sodium 
• 120-72-9 indole 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 265111-01-1 1-(5-bromo-1-tosyl-1H-indol-3-yl)ethan-1-one 
• 1092102-04-9 5-(oct-1-ynyl)-1-tosyl-1H-indole 
• 1197026-54-2 methyl (R)-N-(tert-butoxycarbonyl)-2-(3-(1-tosylindol-5-yl)-4-methoxyphenyl)glycinate 
• 1202766-00-4 C₁₇H₁₄BrHgNO₄S 
• 1191382-28-1 C₁₉H₁₈BrNO₃S 
• 1191382-29-2 C₂₁H₂₂BrNO₃S 
• 1191382-32-7 [(5-bromo-1-tosyl-1H-indol-2-yl)phenyl]methanol 
• 1191382-31-6 C₁₆H₁₂BrNO₃S 
• 1191382-30-5 C₂₃H₂₀BrNO₃S 
• 1191382-27-0 C₁₈H₁₈BrNO₃S 
• 1191382-26-9 C₁₉H₂₀BrNO₃S 
• 1280136-08-4 ethyl 2-methyl-4-phenyl-4-(5-bromo-1-tosyl-1H-indol-2-yl)but-2(Z)-enoate 
• 1280136-09-5 ethyl 2-methyl-4-phenyl-4-(5-bromo-1-tosyl-1H-indol-2-yl)but-2(E)-enoate 

Relevant articles and documents

A Series of 2-((1-Phenyl-1H-imidazol-5-yl)methyl)-1H-indoles as Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising therapeutic target in cancer immunotherapy and neurological disease. Thus, searching for highly active inhibitors for use in human cancers is now a focus of widespread research and development efforts. I

Design, Synthesis, and Antifungal Evaluation of Cryptolepine Derivatives against Phytopathogenic Fungi

Inspired by the widely antiphytopathogenic application of diversified derivatives from natural sources, cryptolepine and its derivatives were subsequently designed, synthesized, and evaluated for their antifungal activities against four agriculturally important fungi Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum. The results obtained from in vitro assay indicated that compounds a1-a24 showed great fungicidal property against B. cinerea (EC50 4 μg/mL); especially, a3 presented significantly prominent inhibitory activity with an EC50 of 0.027 μg/mL. In the pursuit of further expanding the antifungal spectrum of cryptolepine, ring-opened compound f1 produced better activity with an EC50 of 3.632 μg/mL against R. solani and an EC50 of 5.599 μg/mL against F. graminearum. Furthermore, a3 was selected to be a candidate to investigate its preliminary antifungal mechanism to B. cinerea, revealing that not only spore germination was effectively inhibited and the normal physiological structure of mycelium was severely undermined but also detrimental reactive oxygen was obviously accumulated and the normal function of the nucleus was fairly disordered. Besides, in vivo curative experiment against B. cinerea found that the therapeutic action of a3 was comparable to that of the positive control azoxystrobin. These results suggested that compound a3 could be regarded as a novel and promising agent against B. cinerea for its valuable potency.

B(C6F5)3-Catalyzed Highly Chemoselective Reduction of Isatins: Synthesis of Indolin-3-ones and Indolines

A chemo- and site-selective reduction reaction of isatin derivatives using catalyst B(C6F5)3 and hydrosilanes is described. This transformation is operationally simple, proceeds under mild conditions, and is resistant to various functional groups. Thus, this efficient reaction using a combination of B(C6F5)3 and BnMe2SiH or B(C6F5)3 and Et2SiH2 could potentially be utilized to produce various indolin-3-ones and indolines, without the need for multistep procedures and metal catalysis conditions.