99419-61-1

Basic information

• Product Name: 1-chloro-1-(3-nitrophenyl)ethylene
• Synonyms: 1-chloro-1-(3-nitrophenyl)ethylene
• CAS NO: 99419-61-1
• Molecular Weight: 183.594
• Mol File: 99419-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-chloro-1-(3-nitrophenyl)ethylene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-1-(3-nitrophenyl)ethylene(99419-61-1)
• EPA Substance Registry System: 1-chloro-1-(3-nitrophenyl)ethylene(99419-61-1)

Safety Data

• Hazardous Substances Data: 99419-61-1(Hazardous Substances Data)

Usage

Chlorinated derivative of nitrostyrene

This compound contains a nitro group (-NO2) and a chlorine atom (-Cl) attached to a styrene backbone (a vinyl group attached to a benzene ring).

Organic synthesis precursor

1-chloro-1-(3-nitrophenyl)ethylene is commonly used as a starting material in organic synthesis, allowing for the creation of various other chemical compounds through different reactions.

Potential applications

1-chloro-1-(3-nitrophenyl)ethylene has been studied for its possible uses in pharmaceuticals and materials science, indicating its versatility and importance in these fields.

Hazardous properties

It is crucial to handle and dispose of 1-chloro-1-(3-nitrophenyl)ethylene with care, as it may pose risks to human health and the environment if not properly managed.

Upstream product

• 121-89-1 3-Nitroacetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 54060-30-9 3-acetylenephenylamine 
• 183319-69-9 erlotinib hydrochloride 
• 3034-94-4 3-nitrophenylacetylene 

Relevant articles and documents

A synthesis method of erlotinib hydrochloride (by machine translation)

The invention relates to a technical field of drug synthesis, relates to a new synthetic method of erlotinib hydrochloride. The steps are as follows: 1) to acetophenone as a starting material, in the nitration reaction takes place in the mixed between nitro acetophenone; 2) between nitro acetophenone with chlorinated reagent in the organic solvent in the reaction of chloride 1 - chloro - 1 - (3 - nitrophenyl) ethylene; 3) 1 - chloro - 1 - (3 - nitrophenyl) ethylene in the presence of an organic solvent and alkali to obtain between the dehydrochlorination nitrobenzene acetylene; 4) m acetylene through the nitro-selective reduction to obtain between amino acetylene; reduction method as a reducing agent or catalytic hydrogenation reduction; 5) between amino acetylene and 4 - chloro - 6, 7 - b - (2 - methoxyethoxy) quinazoline in reaction of organic solvent to obtain the erlotinib hydrochloride; raw materials of the invention is cheap, low production cost, simple operation, mild reaction conditions and the like, and is suitable for industrial production. (by machine translation)