99745-88-7 Usage
Description
trans-1-Hydroxy-2,7-diaminomitosene is a chemical compound derived from Mitomycin C, an antitumor antibiotic. It possesses antineoplastic properties, making it a potential candidate for cancer treatment.
Uses
Used in Oncology:
trans-1-Hydroxy-2,7-diaminomitosene is used as an antineoplastic agent for the treatment of various types of cancer. Its mechanism of action involves the inhibition of DNA synthesis and function, leading to the prevention of tumor growth and proliferation.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, trans-1-Hydroxy-2,7-diaminomitosene is utilized as an active pharmaceutical ingredient in the development of cancer therapeutics. Its antineoplastic properties make it a valuable component in the creation of drugs aimed at combating cancer.
Used in Research and Development:
trans-1-Hydroxy-2,7-diaminomitosene is also used in research and development for the study of its antineoplastic properties and potential applications in cancer treatment. This includes investigations into its mechanism of action, efficacy, and safety in preclinical and clinical studies.
Check Digit Verification of cas no
The CAS Registry Mumber 99745-88-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,7,4 and 5 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 99745-88:
(7*9)+(6*9)+(5*7)+(4*4)+(3*5)+(2*8)+(1*8)=207
207 % 10 = 7
So 99745-88-7 is a valid CAS Registry Number.
99745-88-7Relevant articles and documents
Synthesis of Mitomycin C and Decarbamoylmitomycin C N2 deoxyguanosine-adducts
Champeil, Elise,Cheng, Shu-Yuan,Huang, Bik Tzu,Conchero-Guisan, Marta,Martinez, Thibaut,Paz, Manuel M.,Sapse, Anne-Marie
, p. 90 - 99 (2016/03/01)
Mitomycin C (MC) and Decarbamoylmitomycin C (DMC) - a derivative of MC lacking the carbamate on C10 - are DNA alkylating agents. Their cytotoxicity is attributed to their ability to generate DNA monoadducts as well as intrastrand and interstrand cross-lin
Studies on the reactivity of reductively activated mitomycin C
Schiltz, Pascal,Kohn, Harold
, p. 10510 - 10518 (2007/10/02)
Mitomycin C (1a), a clinically significant antineoplastic antiobiotic, is considered to be the prototype of bioreductive alkylating agents. It has been reported that, in the absence of DNA, reductive activation of 1a furnished both solvolytic C(1) electro
Comparative reactivities of mitomycin C, 7-(N-piperidino)mitomycin, and mitomycin A. The role of the C(7)substituent
Subramaniam,Kohn
, p. 10519 - 10526 (2007/10/02)
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