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3-(4-Methoxyphenoxy)propanoic acid, also known as MPYA, is a chemical compound with the formula C10H12O4. It is a white to off-white crystalline powder with a molecular weight of 196.2 g/mol. This carboxylic acid derivative features a phenolic group and a propionic acid group, making it a versatile building block for the synthesis of various organic compounds. MPYA is commonly used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals.

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  • 20811-60-3 Structure
  • Basic information

    1. Product Name: 3-(4-METHOXYPHENOXY)PROPANOIC ACID
    2. Synonyms: BUTTPARK 80\07-08;IFLAB-BB F1575-0111;AKOS BC-0464;3-(4-METHOXYPHENOXY)PROPANOIC ACID;3-(4-METHOXY-PHENOXY)-PROPIONIC ACID;3-(p-Methoxyphenoxy)propanoic acid;3-(p-Methoxyphenoxy)propionic acid;Propanoic acid,3-(4-Methoxyphenoxy)-
    3. CAS NO:20811-60-3
    4. Molecular Formula: C10H12O4
    5. Molecular Weight: 196.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 20811-60-3.mol
  • Chemical Properties

    1. Melting Point: 110.5 °C
    2. Boiling Point: 321.7 °C at 760 mmHg
    3. Flash Point: 125.6 °C
    4. Appearance: /
    5. Density: 1.188 g/cm3
    6. Vapor Pressure: 0.000121mmHg at 25°C
    7. Refractive Index: 1.523
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 4.14±0.10(Predicted)
    11. CAS DataBase Reference: 3-(4-METHOXYPHENOXY)PROPANOIC ACID(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-(4-METHOXYPHENOXY)PROPANOIC ACID(20811-60-3)
    13. EPA Substance Registry System: 3-(4-METHOXYPHENOXY)PROPANOIC ACID(20811-60-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 20811-60-3(Hazardous Substances Data)

20811-60-3 Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Methoxyphenoxy)propanoic acid is used as a synthetic intermediate for the manufacturing of anti-inflammatory drugs. Its unique chemical structure allows for the development of medications that can effectively reduce inflammation and alleviate pain.
Used in Agrochemical Industry:
3-(4-Methoxyphenoxy)propanoic acid is used as a synthetic intermediate for the production of herbicides and fungicides. Its versatile chemical properties enable the creation of effective agricultural chemicals that protect crops from weeds and fungal infections, ensuring higher crop yields and better food security.

Check Digit Verification of cas no

The CAS Registry Mumber 20811-60-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,8,1 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 20811-60:
(7*2)+(6*0)+(5*8)+(4*1)+(3*1)+(2*6)+(1*0)=73
73 % 10 = 3
So 20811-60-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O4/c1-13-8-2-4-9(5-3-8)14-7-6-10(11)12/h2-5H,6-7H2,1H3,(H,11,12)

20811-60-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-METHOXYPHENOXY)PROPANOIC ACID

1.2 Other means of identification

Product number -
Other names 3-(4-Methoxyphenoxy)propionic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20811-60-3 SDS

20811-60-3Relevant articles and documents

Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents

Cai, Jin,Chen, Xixi,Huang, Mingqi,Ji, Min,Wang, Yuhong

, (2021/08/09)

Three series of bitopic benzopyranomorpholine analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined using the method of radioligand binding assay. Most compounds demonstrated considerable binding affinities and selectivity for D3 receptor. Besides, the compounds were screened for their ability to alleviate withdrawal symptoms of opioid addiction in animal behavioral models. The results showed that compound 20h displayed nanomolar affinity for the D3R, and exhibited anti-drug addiction efficacy in the animal model of of naloxone-induced withdrawal symptoms in morphine-dependent mice.

Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones

Begum, Ayisha F.,Balasubramanian, Kalpattu K.,Shanmugasundaram, Bhagavathy

supporting information, (2021/09/13)

3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.

Hydrated ferric sulfate-catalyzed reactions of indole with aldehydes, ketones, cyclic ketones, and chromanones: Synthesis of bisindoles and trisindoles

Noland, Wayland E.,Kumar, Honnaiah Vijay,Flick, Grant C.,Aspros, Cole L.,Yoon, Jong Hyeon,Wilt, Andre C.,Dehkordi, Nasim,Thao, Sheng,Schneerer, Andrew K.,Gao, Siming,Tritch, Kenneth J.

, p. 3913 - 3922 (2017/06/13)

Hydrated ferric sulfate [Fe2(SO4)3·xH2O] has been found to be an efficient catalyst for condensation of bisindoles or trisindoles with aliphatic or aryl aldehydes and ketones including methyl and ethyl-alkyl ketones, methyl aryl ketones, cyclic ketones, and 4-chromanones in 19–96% yields. Trisindoles and 2,2'-alkylidenebisindoles were obtained from indole-3-carbaldehydes or 3-methylindole in 72–84% yields. A total of 43 substrates was employed, giving 33 bisindoles, 3 trisindoles, and one 2:2 product; seventeen of these are new. The best results were obtained from heating ethanolic suspensions, with Fe2(SO4)3·xH2O loaded at 60 mg per mmol of electrophiles. The reaction times were typically 1–4 h, while hindered electrophiles required 8–24 h. These conditions were strong enough to promote 2:1 condensation of indole with substrates without forming higher-order byproducts, with few exceptions. This strategy features tolerance by the catalyst of a wide range of functional groups, readily available starting materials, simple operation, mild reaction conditions, and is environmentally friendly.

METHOD OF TREATING POLYCYSTIC KIDNEY DISEASES WITH CERAMIDE DERIVATIVES

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Paragraph 0182; 0183, (2016/10/08)

PROBLEM TO BE SOLVED: To provide a method of treating polycystic kidney diseases with ceramide derivatives. SOLUTION: A pharmaceutical composition for treating polycystic kidney disease in a subject comprises an effective amount of a predetermined compoun

Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease

-

Page/Page column 68-69, (2016/11/21)

A method of treating a glomerular disease selected from the group consisting of mesangial proliferative glomerulonephritis, collapsing glomerulopathy, proliferative lupus nephritis, crescentic glomerulonephritis and membranous nephropathy in a subject com

Efficient and rapid synthesis of phenolic analogs of 4-phenylbutanoic acid using microwave-assisted Michael addition as a key reaction

Iida, Hirokazu,Akatsu, Yusuke,Mizukami, Kazushi,Natori, Sho,Matsukawa, Minako,Takahashi, Kie

supporting information, p. 581 - 585 (2016/07/06)

ABSTRACT: The addition of phenols to acrylonitrile in the presence of aqueous benzyltrimethylammonium hydroxide or tetramethylammonium hydroxide under microwave irradiation yielded the corresponding Michael adducts. The obtained adducts were easily transformed to phenolic analogs of 4-phenylbutanoic acids via the hydrolysis of nitrile groups.

Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors

Vandenberg, Richard J.B.H.N.,Vanrijssel, Erwin R.,Ferraz, Maria Joao,Houben, Judith,Strijland, Anneke,Donker-Koopman, Wilma E.,Wennekes, Tom,Bonger, Kimberly M.,Ghisaidoobe, Amar B. T.,Hoogendoorn, Sascha,Vandermarel, Gijsbert A.,Codée, Jeroen D. C.,Overkleeft, Herman S.,Aerts, Johannes M. F. G.

, p. 2042 - 2062 (2015/12/23)

Glucosylceramide metabolism and the enzymes involved have attracted significant interest in medicinal chemistry, because aberrations in the levels of glycolipids that are derived from glucosylceramide are causative in a range of human diseases including lysosomal storage disorders, type2 diabetes, and neurodegenerative diseases. Selective modulation of one of the glycoprocessing enzymes involved in glucosylceramide metabolism - glucosylceramide synthase (GCS), acid glucosylceramidase (GBA1), or neutral glucosylceramidase (GBA2) - is therefore an attractive research objective. In this study we took two established GCS inhibitors, one based on deoxynojirimycin and the other a ceramide analogue, and merged characteristic features to obtain hybrid compounds. The resulting 39-compound library does not contain new GCS inhibitors; however, a potent (200nm) GBA1 inhibitor was identified that has little activity toward GBA2 and might therefore serve as a lead for further biomedical development as a selective GBA1 modulator. Taking the best of both: Two established glucosylceramide synthase (GCS) inhibitors were merged via convergent synthesis to obtain hybrid compounds. Members of this 39-compound library have characteristics of both parent GCS inhibitors. No new GCS inhibitors were established, but a potent (200nm) acid glucosylceramidase (GBA1) inhibitor was identified. This adamantanemethyloxypenanoic acid pyrrolidene-substituted derivative of eliglustat can serve as a lead for further biomedical development of selective GBA1 modulators.

2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

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Page/Page column 91, (2010/04/27)

A compound for use in treating polycystic kidney disease is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating polycystic kidney disease in a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Methods of treating in polycystic kidney disease in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof

Synthesis and optical properties of two new PPV derivatives embedded on the surface of PbS nanocrystals

Piatkowski, Piotr,Gadomski, Wojciech,Przybylski, Pawel,Ratajska-Gadomska, Boena

scheme or table, p. 69 - 75 (2010/12/18)

In this work we present the optical characteristics of three PPV derivatives, pure and conjugated with PbS nanocrystals (NCs). Our results exhibit strong dependence of the fluorescence lifetime of the polymers on the PbS concentration. It appears that the

Chroman Compound, Processes for Its Preparation, and Its Pharmaceutical Use

-

Page/Page column 5; 17, (2008/06/13)

The present invention provided a chroman compound, the method of its preparation and pharmaceutical applications. The compound are represented by formula (I) and its pharmaceutical salt, where in :x is for O or S; n is for 2, 3 or 4; R1 is 6-situ or 7-situ halogen, C1-4alkyl, C1-4alkyoxyl, benzyloxy, acylamino; R2 is nitrogen-containing pentatomic or hexahydric substituted heterocyclic ring. The compound is useful to prepare anti-arrhythmic drugs, the reaction conditions of the method are mild, the raw material are plenty and easy to be obtained, and the operation and post-treatment are simple.

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