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CONVALLATOXIN

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CONVALLATOXIN

EINECS 208-086-3
CAS No. 508-75-8 Density 1.41 g/cm3
Solubility Melting Point 238-239℃ (water )
Formula C29H42 O10 Boiling Point 757.3 °C at 760 mmHg
Molecular Weight 550.71 Flash Point 247.1 °C
Transport Information Appearance
Safety Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes. Risk Codes
Molecular Structure Molecular Structure of 508-75-8 (Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)-) Hazard Symbols
Synonyms

Convallatoxin(6CI,7CI,8CI); Convallaotoxin; Convallaton; Convallatoxine; Convallatoxoside;Convallotoxin; Corglycon; Corglycone; Corglykon; Korglykon; NSC 407808;Strophanthidin a-L-rhamnoside

 

CONVALLATOXIN Chemical Properties

Product Name: Convallatoxin (CAS NO.508-75-8)


Molecular Formula: C29H42O10
Molecular Weight: 550.64g/mol
Mol File: 508-75-8.mol
Einecs: 208-086-3
Boiling point: 757.3 °C at 760 mmHg
Flash Point: 247.1 °C
Density: 1.41 g/cm3
Surface Tension: 70.3 dyne/cm
Enthalpy of Vaporization: 125.86 kJ/mol
Vapour Pressure: 1.8E-26 mmHg at 25°C
XLogP3: -0.7
H-Bond Donor: 5
H-Bond Acceptor: 10

CONVALLATOXIN Uses

 Convallatoxin (CAS NO.508-75-8) is a cardiac drug, similar to digitalis. It is mainly used for acute and chronic heart failure.

CONVALLATOXIN Production

Lily of the valley on the grass part of the whole meal with benzene - ethanol mixture solvent extraction, extract concentration and then with chloroform - ethanol solution of concentrated liquid extract, in turn extracts concentrated, the concentrated solution of water extraction. Concentrated aqueous solution obtained after the cooling, crystallization of a lily of the valley poisoning glycosides crude, crude product recrystallized with methanol that was finished, the lily of the valley-wide grass meal, total yield of 0.01%.

CONVALLATOXIN Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intraduodenal 2100ug/kg (2.1mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
cat LD50 intraperitoneal 180ug/kg (0.18mg/kg)   Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
cat LD50 intravenous 74ug/kg (0.074mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942.
cat LD50 oral 3650ug/kg (3.65mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
cat LDLo unreported 50ug/kg (0.05mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964.
frog LD50 subcutaneous 440ug/kg (0.44mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
frog LDLo intravenous 300ug/kg (0.3mg/kg)   Merck Index. Vol. 10, Pg. 357, 1983.
guinea pig LD50 intraperitoneal 200ug/kg (0.2mg/kg)   Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
guinea pig LD50 intravenous 185ug/kg (0.185mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
guinea pig LD50 oral > 50mg/kg (50mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
guinea pig LD95 intraduodenal 10490ug/kg (10.49mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
monkey LDLo intravenous 90ug/kg (0.09mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
mouse LD50 intraperitoneal 10mg/kg (10mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.
mouse LD50 intravenous 1mg/kg (1mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00462,
mouse LD50 oral > 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
mouse LD50 subcutaneous 15mg/kg (15mg/kg)   Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.
pig LDLo intraduodenal 3170ug/kg (3.17mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
pig LDLo intravenous 50ug/kg (0.05mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
pigeon LDLo intravenous 248ug/kg (0.248mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
rat LD50 intravenous 15200ug/kg (15.2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 848, 1961.

CONVALLATOXIN Safety Profile

Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes.

CONVALLATOXIN Specification

 Convallatoxin ,its CAS NO. is 508-75-8,the synonyms is Strophanthin 3alpha-1-rhamnoside ; Strophanthidin alpha-l-rhamnopyranoside ; Strophanthidin a-l-rhamnopyranoside ; Corglykon ; Convallatoxin;20(22),5beta-cardenolid-19-al-3beta,5beta,14beta-triol-3beta-d-[a-1-rhamnopyranoside] ; 5Beta,20[22]-cardenolide-19-one-3beta,5alpha,14-triol-3-[6-deoxy-alpha-l-mannopyranosyl] ; 3Beta,5alpha,14-trihydroxy-19-oxo-5beta,20[22]-cardenolide-3-[6-deoxy-alpha-l-mannopyranosyl] .

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