- Cucurbitacin A
- CUCURBITACIN B
- Cucurbitacin D
- Cucurbitacin E
- Cucurbitacin I
- Cucurbitacin IIA
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| Name |
CUCURBITACIN B |
EINECS | N/A |
| CAS No. | 6199-67-3 | Density | 1.23 g/cm3 |
| PSA | 138.20000 | LogP | 3.49930 |
| Solubility | N/A | Melting Point |
184-186oC |
| Formula | C32H46O8 | Boiling Point | 699.3 °C at 760 mmHg |
| Molecular Weight | 558.712 | Flash Point | 218.7 °C |
| Transport Information | N/A | Appearance | White powder |
| Safety | 45-24/25 | Risk Codes | 25 |
| Molecular Structure |
|
Hazard Symbols | T |
| Synonyms |
19-Nor-9b,10a-lanosta-5,23-diene-3,11,22-trione, 2b,16a,20,25-tetrahydroxy-9-methyl-, 25-acetate (7CI,8CI);(+)-Cucurbitacin B;Amarine;Cucurbitacine B;NSC 144154;NSC49451;Cucurbitacin B;[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate;Cucurbitacin B hydrate; |
CUCURBITACIN B Chemical Properties
CUCURBITACIN B's Molecular formula: C32H46O8
CUCURBITACIN B's Molar mass: 558.7
Synonyms: (2beta,9beta,10alpha,16alpha,23e)-thyl;19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25;19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet;19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me;25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr;cucurbitacineb;AMARINE;1,2-DIHYDRO-ALPHA-ELATERIN
CUCURBITACIN B Toxicity Data With Reference
| 1. | orl-mus LD50:14 mg/kg | CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605. | ||
| 2. | scu-mus LD50:1 mg/kg | CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605. | ||
| 3. | ims-mus LD50:2730 µg/kg | CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605. |
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 2730ug/kg (2.73mg/kg) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992. | |
| mouse | LD50 | oral | 14mg/kg (14mg/kg) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992. | |
| mouse | LD50 | subcutaneous | 1mg/kg (1mg/kg) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992. |
CUCURBITACIN B Safety Profile
A poison by ingestion, subcutaneous, and intramuscular routes. When heated to decomposition it emits acrid smoke and irritating vapors.
| Safety Info | |
| Symbol: |  GHS06 |
|---|---|
| Sign: | Danger |
| hazard declaration: | H300 |
| hazard declaration add: | |
| waring notice: | P264; P301 + P310 |
CUCURBITACIN B Specification
Cucurbitacin B is a tetracyclic triterpenoid, which can induce apoptosis in human hepatoma cells. It can also induce DNA damage and autophagy in MCF-7 breast cancer cells. In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.
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