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| CAS No.: | 6199-67-3 |
|---|---|
| Name: | CUCURBITACIN B |
| Molecular Structure: | |
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| Formula: | C32H46O8 |
| Molecular Weight: | 558.712 |
| Synonyms: | 19-Nor-9b,10a-lanosta-5,23-diene-3,11,22-trione, 2b,16a,20,25-tetrahydroxy-9-methyl-, 25-acetate (7CI,8CI);(+)-Cucurbitacin B;Amarine;Cucurbitacine B;NSC 144154;NSC49451;Cucurbitacin B;[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate;Cucurbitacin B hydrate; |
| Density: | 1.23 g/cm3 |
| Melting Point: | 184-186oC |
| Boiling Point: | 699.3 °C at 760 mmHg |
| Flash Point: | 218.7 °C |
| Appearance: | White powder |
| Hazard Symbols: | T |
| Risk Codes: | 25 |
| Safety: | 45-24/25 |
| PSA: | 138.20000 |
| LogP: | 3.49930 |
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Chemistry
CUCURBITACIN B's Molecular formula: C32H46O8
CUCURBITACIN B's Molar mass: 558.7
Synonyms: (2beta,9beta,10alpha,16alpha,23e)-thyl;19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25;19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet;19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me;25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr;cucurbitacineb;AMARINE;1,2-DIHYDRO-ALPHA-ELATERIN
Toxicity Data With Reference
| 1. | orl-mus LD50:14 mg/kg | CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605. | ||
| 2. | scu-mus LD50:1 mg/kg | CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605. | ||
| 3. | ims-mus LD50:2730 µg/kg | CTYAD8 Zhongcaoyao. Chinese Herbal Medicine. 23 (1992),605. |
Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 2730ug/kg (2.73mg/kg) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992. | |
| mouse | LD50 | oral | 14mg/kg (14mg/kg) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992. | |
| mouse | LD50 | subcutaneous | 1mg/kg (1mg/kg) | Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 23, Pg. 605, 1992. |
Safety Profile
Specification
Cucurbitacin B is a tetracyclic triterpenoid, which can induce apoptosis in human hepatoma cells. It can also induce DNA damage and autophagy in MCF-7 breast cancer cells. In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.