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Basic Information
CAS No.: 11003-38-6
Name: Capreomycin
Molecular Structure:
Molecular Structure of 11003-38-6 (Capreomycin)
Formula: C50H88N28O15
Molecular Weight: 1321.41232
Synonyms: Capastat;Capostatin; Capreomicin; Capromycin
Boiling Point: 1376.7°C at 760 mmHg
Flash Point: 786.4°C
Safety: A poison by intravenous route. Moderately toxic by subcutaneous route. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.
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    High quality; CAPREOMYCIN ;CAS NO:11003-38-6

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  • Capreomycin

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    Capreomycin

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    Capreomycin

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Chemistry

Chemistry informtion about Capreomycin (CAS NO.11003-38-6) is:
IUPAC Name: 3,6-diamino-N-[[(4Z)-11-amino-7-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-4-[(carbamoylamino)methylidene]-14-(hydroxymethyl)-2,5,8,12,15-pentaoxo-3,6,9,13,16-pentazacyclohexadec-1-yl]methyl]hexanamide; sulfuric acid
Synonyms: 3,6-Diamino-N-[[(8z)-15-Amino-11-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-2-(Hydroxymethyl)-3,6,9,12,16-Pentaoxo-8-(Ureidomethylene)-1,4,7,10,13-Pentazacyclohexadec-5-Yl]Methyl]Hexanamide ; Sulfuric Acid
MF: C25H46N14O12S
MW: 766.7843 
Flash Point: 786.4 °C
Boiling Point: 1376.7 °C at 760 mmHg
Enthalpy of Vaporization: 234.62 kJ/mol
Following is the molecular structure of Capreomycin (CAS NO.11003-38-6) is:

Production

Raw materials: Cation exchange resin,strong acidic styrene --> Cation exchange resin,weak acidic acrylic acid

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1371mg/kg/96D (1371mg/kg)

vascular: bp elevation not characterized in autonomic section

 American Journal of Kidney Diseases. Vol. 7, Pg. 245, 1986.
mouse LD50 intravenous 238mg/kg (238mg/kg)   Yakkyoku. Pharmacy. Vol. 25, Pg. 353, 1974.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 861, 1967.
mouse LD50 subcutaneous 514mg/kg (514mg/kg)   Yakkyoku. Pharmacy. Vol. 25, Pg. 353, 1974.

Safety Profile

A poison by intravenous route. Moderately toxic by subcutaneous route. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Specification

 Capreomycin (CAS NO.11003-38-6) is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for tuberculosis. Adverse effects include nephrotoxicity and 8th cranial nerve toxicity.The drug should not be given with streptomycin or other drugs that may damage the 8th nerve.