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| CAS No.: | 66592-87-8 |
|---|---|
| Name: | Cefadroxil |
| Molecular Structure: | |
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|
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| Formula: | C16H17N3O5S.H2O |
| Molecular Weight: | 381.409 |
| Synonyms: | 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-,monohydrate, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[amino(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-, monohydrate,[6R-[6a,7b(R*)]]-;Cefadroxil monohydrate;Duricef;? Cefadroxil monohydrate; |
| EINECS: | 256-555-6 |
| Melting Point: | 197oC |
| Boiling Point: | 789.9 °C at 760 mmHg |
| Flash Point: | 431.5 °C |
| Appearance: | White crystalline solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 36/37/38-42/43 |
| Safety: | 26-36 |
| PSA: | 167.49000 |
| LogP: | 1.11530 |
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Chemistry
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IUPAC Name: (6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
Canonical SMILES: CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
Isomeric SMILES: CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)SC1)C(=O)O.O
InChI: InChI=1S/C16H17N3O5S.H2O/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8;/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24);1H2/t10-,11-,15-;/m1./s1
InChIKey: NBFNMSULHIODTC-CYJZLJNKSA-N
Molecular Weight: 381.40356 [g/mol]
Molecular Formula: C16H19N3O6S
H-Bond Donor: 5
H-Bond Acceptor: 7
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds
Flash Point: 431.5 °C
Enthalpy of Vaporization: 120.5 kJ/mol
Boiling Point: 789.9 °C at 760 mmHg
Vapour Pressure: 2.71E-26 mmHg at 25 °C
Appearance: White Crystalline Solid
Melting Point: 197 °C
Classification Code of Cefadroxil (CAS NO.66592-87-8): Antibacterial; Drug / Therapeutic Agent
Uses
Cefadroxil (CAS NO.66592-87-8) is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of Cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat.
Toxicity Data With Reference
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source mouse LD50 intraperitoneal > 6gm/kg (6000mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982. mouse LD50 oral > 10gm/kg (10000mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982. mouse LD50 subcutaneous > 8gm/kg (8000mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982. rat LD50 intraperitoneal > 6gm/kg (6000mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982. rat LD50 oral > 10gm/kg (10000mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982. rat LD50 subcutaneous > 8gm/kg (8000mg/kg) Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 1128, 1982.
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 36/37/38-42/43
R36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: XI0337000
Specification
Cefadroxil (CAS NO.66592-87-8), its Synonyms are (6R,7R)-7-((R)-2-Amino-2-(p-hydroxyphenyl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monohydrate ; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, monohydrate, (6R-(6alpha,7beta(R*)))- ; BL-S 578 ; Baxan Kapseln ; Bidocel ; Cefadroxil 1-wasser ; Cefadroxil monohydrate ; Cefos Granulat ; Duricef ; Kefroxil Kapseln ; MJF 11567-3 ; Moxacef Kapseln ; Omnidrox Kapseln .