Sirtuin Inhibitors
Sirtuin inhibitors are compounds that target sirtuins, a family of NAD+-dependent protein deacetylases and ADP-ribosyltransferases involved in regulating various cellular processes such as metabolism, stress response, and aging. Sirtuins play a critical role in maintaining cellular homeostasis by deacetylating histones and non-histone proteins, thereby influencing gene expression, DNA repair, and mitochondrial function. Inhibition of sirtuins alters these cellular processes, potentially impacting pathways associated with longevity and age-related diseases.
