IAP inhibitors
IAP inhibitors, or inhibitors of apoptosis proteins, are a class of molecules that target a family of proteins known as inhibitor of apoptosis proteins (IAPs). These proteins play a crucial role in regulating apoptosis (programmed cell death) by inhibiting caspases, which are key enzymes involved in the apoptotic process. IAP inhibitors work by binding to IAP proteins, particularly those such as XIAP (X-linked inhibitor of apoptosis protein), cIAP1 (cellular inhibitor of apoptosis protein 1), and cIAP2 (cellular inhibitor of apoptosis protein 2), thereby preventing their interaction with caspases. This interference allows caspases to become activated, leading to apoptosis in cells that would otherwise evade cell death. By blocking IAP proteins, these inhibitors can sensitize cancer cells to apoptosis-inducing signals and promote cell death in malignancies where apoptosis resistance is a factor.
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