CRM1 inhibitors

CRM1 inhibitors, also known as exportin-1 inhibitors, target the nuclear export protein CRM1 (chromosome region maintenance 1), which is crucial for the transport of proteins and RNA molecules from the nucleus to the cytoplasm. CRM1 binds to cargo proteins that contain a nuclear export signal (NES), facilitating their export through the nuclear pore complex. This process is essential for regulating cellular functions such as gene expression, cell cycle progression, and apoptosis. By inhibiting CRM1, these inhibitors block the nuclear export of proteins that are involved in oncogenic pathways, such as tumor suppressors and cell cycle regulators. This can lead to the accumulation of these proteins in the nucleus, altering gene expression patterns and inducing apoptosis in cancer cells.