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Chlordane

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Name

Chlordane

EINECS 200-349-0
CAS No. 57-74-9 Density 1.75g/cm3
PSA 0.00000 LogP 5.68280
Solubility

Stability

    Stable, but readily decomposed by moderately strong alkaline solutions. Corrodes iron and zinc andattacks some types of polymer. Incompatible with strong oxidizing agents.

Toxicology

    Toxic if in
Melting Point 106 - 107 C
Formula C10H6 Cl8 Boiling Point 449.2°Cat760mmHg
Molecular Weight 409.782 Flash Point 229.6°C
Transport Information N/A Appearance off-white powder
Safety 36/37-60-61-36-33-26-16-45-7-62-29-9 Risk Codes 21/22-40-50/53-36/37/38-11-39/23/24/25-23/24/25-67-65-38
Molecular Structure Molecular Structure of 57-74-9 (CHLORDANE) Hazard Symbols An animal carcinogen. Toxic by ingestion, inhalation, and skin absorption. TLV: 0.5 mg/m3.
Synonyms

4,7-Methanoindan,1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro- (6CI,8CI);1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-endomethyleneindane;1,2,4,5,6,7,10,10-Octachloro-4,7,8,9-tetrahydro-4,7-methyleneindane;1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane;CD 68;Chlorindan;Cortilan-neu;Dowchlor;ENT 9932;HCS 3260;M 140;NSC 8931;Octachloro-4,7-methanotetrahydroindane;Oktaterr;Tat Chlor 4;Toxichlor;

Article Data 8

Chlordane Consensus Reports

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 53 , 1991,p. 115.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 53 , 1991,p. 115.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Inadequate Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 53 , 1991,p. 115.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Chlordane Specification

The Chlordane, with the CAS registry number 57-74-9,is also known as CD 68; 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetrahydroindane. It belongs to the product categories of Method Specific;Oeko-Tex Standard 100;PesticidesMethod Specific. This chemical's molecular formula is C10H6Cl8 and molecular weight is 409.78. Its EINECS number is 200-349-0.What's more,Its systematic name is Chlordane.It is a off-white powder which is stable, but readily decomposed by moderately strong alkaline solutions. Corrodes iron and zinc and attacks some types of polymer. Incompatible with strong oxidizing agents.It is used as a pesticide. This white solid was sold in the U.S. until 1983 as an insecticide for crops like corn and citrus and on lawns and domestic gardens.

Physical properties about Chlordane are:
(1)ACD/LogP:  5.893; (2)# of Rule of 5 Violations:  1; (3)ACD/LogD (pH 5.5):  5.89; (4)ACD/LogD (pH 7.4):  5.89; (5)ACD/BCF (pH 5.5):  17718.95; (6)ACD/BCF (pH 7.4):  17718.95; (7)ACD/KOC (pH 5.5):  38248.88; (8)ACD/KOC (pH 7.4):  38248.88; (9)#H bond acceptors:  0; (10)#H bond donors:  0; (11)#Freely Rotating Bonds:  0; (12)Index of Refraction:  1.627; (13)Molar Refractivity:  80.279 cm3; (14)Molar Volume:  226.463 cm3; (15)Surface Tension:  54.1319999694824 dyne/cm; (16)Density:  1.809 g/cm3; (17)Flash Point:  212.488 °C; (18)Enthalpy of Vaporization:  65.292 kJ/mol; (19)Boiling Point:  424.685 °C at 760 mmHg; (20)Vapour Pressure:  0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Cl/C2=C(\Cl)C3(Cl)C1CC(Cl)C(Cl)C1C2(Cl)C3(Cl)Cl;
(2)Std. InChI:InChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2;
(3)Std. InChIKey:BIWJNBZANLAXMG-UHFFFAOYSA-N.

The toxicity data of Chlordane as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LC50 inhalation 100mg/m3/4H (100mg/m3) behavioral: somnolence (general depressed activity) behavioral: convulsions or effect on seizure threshold behavioral: excitement Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 8(4), Pg. 30, 1964.
chicken LD50 oral 220mg/kg (220mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 226, 1966.
domestic animals - goat/sheep LD50 oral 50mg/kg (50mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 471, 1981.
duck LD50 oral 1200mg/kg (1200mg/kg)   Down to Earth. Vol. 35, Pg. 25, 1979.
hamster LD50 oral 1720mg/kg (1720mg/kg)   European Journal of Toxicology and Environmental Hygiene. Vol. 7, Pg. 159, 1974.
human LDLo oral 29mg/kg (29mg/kg) liver: fatty liver degeration "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.
human LDLo skin 428mg/kg (428mg/kg) behavioral: tremor behavioral: convulsions or effect on seizure threshold behavioral: ataxia "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 648, 1969.
mammal (species unspecified) LC50 inhalation > 20gm/m3/4H (20000mg/m3)   Pesticide Manual. Vol. 9, Pg. 139, 1991.
mammal (species unspecified) LD50 oral 180mg/kg (180mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 226, 1966.
man LDLo unreported 118mg/kg (118mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 3071ug/kg (3.071mg/kg) behavioral: coma lungs, thorax, or respiration: dyspnea gastrointestinal: nausea or vomiting Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 291, 1983.
mouse LD50 intravenous 100mg/kg (100mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04876,
mouse LD50 oral 145mg/kg (145mg/kg)   Agricultural Research Service, USDA Information Memorandum. Vol. 20, Pg. 19, 1966.
mouse LDLo intraperitoneal 240mg/kg (240mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.
rabbit LD50 oral 100mg/kg (100mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 226, 1966.
rabbit LD50 skin 780mg/kg (780mg/kg)   "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976.
rabbit LDLo intravenous 10mg/kg (10mg/kg)   Archives of Industrial Hygiene and Occupational Medicine. Vol. 1, Pg. 13, 1950.
rat LD50 intraperitoneal 343mg/kg (343mg/kg)   Toxicology and Applied Pharmacology. Vol. 32, Pg. 443, 1975.
rat LD50 oral 200mg/kg (200mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 614, 1967.
rat LD50 skin 690mg/kg (690mg/kg)   Journal of the American Veterinary Medical Association. Vol. 157, Pg. 1835, 1970.
women LDLo oral 120ug/kg (0.12mg/kg) behavioral: convulsions or effect on seizure threshold behavioral: excitement gastrointestinal: gastritis "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956Vol. -, Pg. 1, 1956.

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