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Name |
Chrysophanic acid |
EINECS | 207-572-2 |
CAS No. | 481-74-3 | Density | 1.476 g/cm3 |
PSA | 74.60000 | LogP | 2.18160 |
Solubility | water: <0.1 g/100 mL at 18 °C | Melting Point |
194-198 °C |
Formula | C15H10O4 | Boiling Point | 489.495 °C at 760 mmHg |
Molecular Weight | 254.242 | Flash Point | 263.939 °C |
Transport Information | N/A | Appearance | yellow crystalline solid or brown powder |
Safety | 26-37/39 | Risk Codes | 36/37/38 |
Molecular Structure | Hazard Symbols | Xi | |
Synonyms |
1,8-Dihydroxy-3-methylanthraquinone;9,10-Anthracenedione, 1,8-dihydroxy-3-methyl- (9CI);1,8-dihydroxy-3-methyl-9,10-anthraquinone;C.I. Natural Yellow 23;Anthraquinone, 1,8-dihydroxy-3-methyl-;Chrysophansaeure;9,10-Anthracenedione, 1, 8-dihydroxy-3-methyl-;3-Methyl-1, 8-dihydroxyanthraquinone;9,10-Anthracenedione,1,8-dihydroxy-3- methyl-; |
Article Data | 83 |
8-hydroxy-1-methoxy-3-methylanthracene-9,10-dione
Chrysophanol
Conditions | Yield |
---|---|
With hydrogen bromide In acetic acid for 5h; Heating; | 100% |
With hydrogen bromide In acetic acid for 5h; Heating; | 100% |
With hydrogen bromide; acetic acid Yield given; |
Chrysophanol 8-O-beta-D-glucopyranoside
Chrysophanol
Conditions | Yield |
---|---|
With acetate buffer; β-glucosidase In water at 37℃; for 16h; pH=5.0; | 98% |
(1R,4aS,9aR)-9a-Chloro-8-hydroxy-1-methoxy-3-methyl-1-trimethylsilanyloxy-1,4,4a,9a-tetrahydro-anthraquinone
A
Chrysophanol
B
8-hydroxy-1-methoxy-3-methylanthracene-9,10-dione
Conditions | Yield |
---|---|
1,8-diazabicyclo[5.4.0]undec-7-ene In methanol; dichloromethane Ambient temperature; | A n/a B 96% |
sodium acetate In methanol; dichloromethane Ambient temperature; Yield given. Yields of byproduct given; |
1,8-dimethoxy-3-methyl-9,10-anthraquinone
Chrysophanol
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid for 0.5h; Heating; | 94% |
With hydrogen bromide In acetic acid for 0.5h; Heating; | 94% |
With nicotinic acid; sulfuric acid; boric acid at 120℃; for 2h; | 45% |
Conditions | Yield |
---|---|
With boron tribromide In dichloromethane at -50℃; for 7h; | 93% |
With aluminium trichloride In dichloromethane at 20℃; | 91% |
With hydrogen bromide; acetic acid | |
With hydrogen bromide for 0.5h; |
3-Bromojuglone
(1E,3Z)-1-Methoxy-3-methyl-1,4-bis-trimethylsilanyloxy-buta-1,3-diene
Chrysophanol
Conditions | Yield |
---|---|
Stage #1: 3-Bromojuglone; (1E,3Z)-1-Methoxy-3-methyl-1,4-bis-trimethylsilanyloxy-buta-1,3-diene In benzene for 5h; Heating; Stage #2: With hydrogenchloride In tetrahydrofuran for 2h; Heating; Further stages.; | 79% |
1,4,4a,9a-Tetrahydro-1,8-dihydroxy-3-methyl-9,10-anthrachinon
Chrysophanol
Conditions | Yield |
---|---|
With pyridinium chlorochromate In dichloromethane for 4h; | 76% |
With pyridinium chlorochromate |
1,6,8-trihydroxy-3-methyl-9,10-anthraquinone
A
Chrysophanol
B
(R)-3,4-dihydro-3,8,9,10-tetrahydroxy-6-methylanthracen-1(2H)-one
Conditions | Yield |
---|---|
With glucose dehydrogenase; sodium dithionite; β-D-glucose; Talaromyces islandicus anthrol reductase; nicotinamide adenine dinucleotide phosphate In aq. phosphate buffer; dimethyl sulfoxide for 14h; pH=7; Inert atmosphere; Enzymatic reaction; stereoselective reaction; | A 12% B 74% |
With glucose dehydrogenase; sodium dithionite; D-glucose; anthrol reductase of Talaromyces islandicus WF-38-12; NADP In aq. buffer for 14h; pH=7; Catalytic behavior; Kinetics; pH-value; Enzymatic reaction; stereoselective reaction; | A n/a B 74% |
Stage #1: 1,6,8-trihydroxy-3-methyl-9,10-anthraquinone With sodium dithionite Stage #2: With N-terminally His-tagged 17β-hydroxysteroid dehydrogenase from the filamentous fungus Curvularia lunata (teleomorph Cochlioboluslunatus) cloned into pET19b; NADPH Enzymatic reaction; | A 8% B 32% |
With sodium dithionite; D-glucose; his-tagged AflM from Aspergillus parasiticus; C21H27N7O17P3(1-)*Na(1+) In aq. phosphate buffer at 20℃; for 24h; pH=7; Inert atmosphere; Enzymatic reaction; | A 8 %Spectr. B 20% |
(R)-3,4-dihydro-3,8,9,10-tetrahydroxy-6-methylanthracen-1(2H)-one
A
Chrysophanol
B
1,6,8-trihydroxy-3-methyl-9,10-anthraquinone
C
(−)-flavoskyrin
Conditions | Yield |
---|---|
With oxygen In aq. phosphate buffer; acetonitrile at 10℃; for 10h; pH=6; Solvent; | A 10% B n/a C 72% |
(R)-3,4-dihydro-3,8,9,10-tetrahydroxy-6-methylanthracen-1(2H)-one
A
Chrysophanol
Conditions | Yield |
---|---|
With lead(IV) tetraacetate; acetic acid at 0 - 20℃; for 0.333333h; | A 8% B 68% |
IUPAC Name: 1,8-Dihydroxy-3-methylanthracene-9,10-dione
Molecular formula: C15H10O4
Molecular Weight: 254.24
EINECS: 207-572-2
Melting point: 194-198 °C
Boiling Point: 489.5 °C at 760 mmHg
Flash Point: 263.9 °C
Index of Refraction: 1.709
Molar Refractivity: 67.25 cm3
Molar Volume: 172.2 cm3
Surface Tension: 73.1 dyne/cm
Density: 1.476 g/cm3
Enthalpy of Vaporization: 78.46 kJ/mol
Vapour Pressure: 3.31E-10 mmHg at 25 °C
Water Solubility: <0.1 g/100 mL at 18 °C
Stability: Stable. Incompatible with strong oxidizing agents.
Appearance: yellow crystalline solid or brown powder
Classification Code of Chrysophanol (CAS NO.481-74-3): Mutagens; Mutation data; Noxae
Hazard Codes of Chrysophanol (CAS NO.481-74-3): Xi
Risk Statements:
36/37/38: Irritating to eyes, respiratory system and skin
36/38: Irritating to eyes and skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
36: Wear suitable protective clothing
WGK Germany: 3
RTECS: CB6725000
Chrysophanol (CAS NO.481-74-3), its Synonyms are 1,8-Dihydroxy-3-methyl-9,10-anthracenedione ; 1,8-Dihydroxy-3-methylanthraquinone ; 3-Methylchrysazin ; 4,5-Dihydroxy-2-methylanthraquinone ; Chrysophanic acid ; Turkey rhubarb ; 9,10-Anthracenedione, 1,8-dihydroxy-3-methyl- ; 9,10-Anthracenedione, 1,8-dihydroxy-3-methyl- (9CI) ; Anthraquinone, 1,8-dihydroxy-3-methyl- .