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IUPAC Name: 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
Synonyms of Clobutinol (CAS NO.14860-49-2) : 1-(4-Chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol ; 1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol ; 4-Chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methylbenzeneethanol ; Biotertussin
CAS NO:14860-49-2
Molecular Formula:C14H22ClNO
Molecular Weight :255.7836
Molecular Structure :
EINECS: 238-926-4
Index of Refraction: 1.53
Surface Tension: 38.3 dyne/cm
Density: 1.072 g/cm3
Flash Point: 169.6 °C
Enthalpy of Vaporization: 63.54 kJ/mol
Boiling Point: 356.8 °C at 760 mmHg
Vapour Pressure: 1.04E-05 mmHg at 25°C
Clobutinol (CAS NO.14860-49-2) is a cough suppressant.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 45300ug/kg (45.3mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974. | |
mouse | LD50 | intraperitoneal | 128mg/kg (128mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975. | |
mouse | LD50 | intravenous | 53mg/kg (53mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975. | |
mouse | LD50 | oral | 334mg/kg (334mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975. | |
mouse | LD50 | subcutaneous | 262mg/kg (262mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974. | |
rat | LD50 | intraperitoneal | 165mg/kg (165mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975. | |
rat | LD50 | intravenous | 63mg/kg (63mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975. | |
rat | LD50 | oral | 802mg/kg (802mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975. | |
rat | LD50 | subcutaneous | 775mg/kg (775mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 119, 1975. |
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also ALCOHOL, DENATURED; ALCOHOLS, C6-12; ALCOHOLS, C9-11; ALCOHOLS, C12-13, ETHOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED; ALCOHOLS, C12-16, ETHOXYLATED; ALCOHOLS, C14-15, ETHOXYLATED; ALCOHOLS, C16-18, ETHOXYLATED; ALCOHOLS, C8-10, ETHOXYLATED PROPOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED PROPOXYLATED; ALCOHOLS, N.O.S..
Clobutinol (CAS NO.14860-49-2) was recently determined to cause cardiac arrhythmia in some patients.Recent studies have indicated that clobutinol has the potential to prolong the QT interval.Boehringer Ingelheim products containing clobutinol were withdrawn from sale in Germany, and the rest of the world, on August 31, 2007