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Cyclohexene oxide

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Name

Cyclohexene oxide

EINECS 206-007-7
CAS No. 286-20-4 Density 0.97 g/cm3
PSA 12.53000 LogP 1.32780
Solubility Insoluble in water, soluble in alcohol, acetone, ether Melting Point -40 °C
Formula C6H10O Boiling Point 130.3 °C at 760 mmHg
Molecular Weight 98.1448 Flash Point 27.2 °C
Transport Information UN 2924 3/PG 3 Appearance clear colorless to yellow liquid
Safety 26-36/37/39-45-16 Risk Codes 10-20/21/22-34
Molecular Structure Molecular Structure of 286-20-4 (Cyclohexene oxide) Hazard Symbols CorrosiveC
Synonyms

1,2-Cyclohexeneoxide;1,2-Epoxycyclohexane;2,3-Tetramethyleneoxirane;Cyclohexane,1,2-epoxy-;Cyclohexene epoxide;Cyclohexylene oxide;NSC128074;NSC 5218;Tetramethyleneoxirane;

Article Data 749

Cyclohexene oxide Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Cyclohexene oxide Specification

The Cyclohexene oxide with CAS registry number of 286-20-4 is also known as Cyclohexane,1,2-epoxy-. The IUPAC name is 7-Oxabicyclo[4.1.0]heptane. It belongs to product categories of Pharmaceutical Intermediates; Alcohol& Phenol& Ethers. Its EINECS registry number is 206-007-7. In addition, the formula is C6H10O and the molecular weight is 98.14. This chemical is a clear colorless to yellow liquid.

Physical properties about Cyclohexene oxide are: (1)ACD/LogP: 1.24; (2)ACD/LogD (pH 5.5): 1.24; (3)ACD/LogD (pH 7.4): 1.24; (4)ACD/BCF (pH 5.5): 5.18; (5)ACD/BCF (pH 7.4): 5.18; (6)ACD/KOC (pH 5.5): 112.91; (7)ACD/KOC (pH 7.4): 112.91; (8)#H bond acceptors: 1; (9)Index of Refraction: 1.479; (10)Molar Refractivity: 27.32 cm3; (11)Molar Volume: 96.2 cm3; (12)Surface Tension: 34.6 dyne/cm; (13)Density: 1.019 g/cm3; (14)Flash Point: 27.2 °C; (15)Enthalpy of Vaporization: 35.27 kJ/mol; (16)Boiling Point: 130.3 °C at 760 mmHg; (17)Vapour Pressure: 12 mmHg at 25 °C.

Preparation of Cyclohexene oxide: it is prepared by reaction of propanol, cyclohexene, dihydroxy-trimethyl antimony, hexacarbonyl tungsten and hydrogen peroxide. This reaction occurs at the temperature of 60 °C for 3 hours. The yield is about 92.5%.

Uses of Cyclohexene oxide: it is used to synthesize pesticide intermediate or surfactant. Besides, it is used to produce trans-2-pyrrolidino-cyclohexanol by reaction with pyrrolidine. The reaction occurs with reagent H2O at 70-90 °C for 28 hours. The yield is about 80%.

Cyclohexene oxide is used to produce trans-2-pyrrolidino-cyclohexanol by reaction with pyrrolidine.

When you are using this chemical, please be cautious about it. As a chemical, it is harmful by inhalation, in contact with skin and if swallowed. It's also flammable and may causes burns. During using it, wear suitable protective clothing, gloves and eye/face protection. What's more, keep away from sources of ignition. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If accident happens or you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1CCC2C(C1)O2
2. InChI: InChI=1S/C6H10O/c1-2-4-6-5(3-1)7-6/h5-6H,1-4H2
3. InChIKey: ZWAJLVLEBYIOTI-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 1gm/kg (1000mg/kg)   Journal of Scientific and Industrial Research, Section C: Biological Sciences. Vol. 21, Pg. 342, 1962.
rabbit LD50 skin 630uL/kg (0.63mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LCLo inhalation 2000ppm/4H (2000ppm)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat LD50 intraperitoneal 549mg/kg (549mg/kg) BEHAVIORAL: TREMOR Toxicology and Applied Pharmacology. Vol. 52, Pg. 422, 1980.
rat LD50 oral 1090uL/kg (1.09mL/kg)   American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

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