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Cyclohexyl acetate

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Cyclohexyl acetate

EINECS 210-736-6
CAS No. 622-45-7 Density 0.966
PSA 26.30000 LogP 1.88220
Solubility Insoluble in water; miscible in ether Melting Point -77 °C
Formula C8H14 O2 Boiling Point 173 °C at 760 mmHg
Molecular Weight 142.198 Flash Point 58 ºC
Transport Information UN 2243 Appearance COLOURLESS LIQUID
Safety Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. Human systemic effects by inhalation: conjunctiva irritation and unspecified respiratory system changes. A systemic irritant to humans. A skin and eye irritant. Flammable liquid when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes. Risk Codes R38   
Molecular Structure Molecular Structure of 622-45-7 (Cyclohexyl acetate) Hazard Symbols
Synonyms

Cyclohexanol,acetate (6CI); Acetic acid cyclohexanyl ester; Acetoxycyclohexane; Cyclohexylacetate; NSC 8772

Article Data 356

Cyclohexyl acetate Chemical Properties

Empirical Formula: C8H14O
Molecular Weight: 142.1956 
IUPAC Name: Cyclohexyl acetate
Synonyms: Adronolacetate ; Cyclohexanolacetate ; Cyclohexanyl acetate ; Acetate-cyclohexano
Melting Point: -77 °C
Boiling Point: 172-173 °C(lit.)
Density of Cyclohexyl acetate (622-45-7): 0.966 g/mL at 25 °C(lit.)
Solubility: -1.67
Refractive index: n20/D 1.439(lit.)
Specific Gravity: 0.971-0.978
FEMA of Cyclohexyl acetate (622-45-7): 2349
Flash Point: 136 °F
Appearance: Cyclohexyl acetate (622-45-7) is an oily liquid; odour reminiscent of amyl acetate

Cyclohexyl acetate Uses

 Cyclohexyl acetate (622-45-7) is used as a spice and maily used in the preparation of apple, banana, black spike-like currant, raspberry and other flavor.

Cyclohexyl acetate Production

 Cyclohexyl acetate (622-45-7) is formed from cyclohexanol and glacial acetic acid or acetic anhydride by ordinary dehydration esterification.

Cyclohexyl acetate Toxicity Data With Reference

1.    

skn-rbt 100 mg/24H MOD

    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,359.
2.    

eye-rbt 500 mg/24H MLD

    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,359.
3.    

ihl-hmn TCLo:3000 mg/m3/45M:IRR

    AHYGAJ    Archiv fuer Hygiene. 78 (1913),260.
4.    

orl-rat LD50:6730 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 28 (1974),313.
5.    

scu-cat LDLo:606 mg/kg

    AHYGAJ    Archiv fuer Hygiene. 78 (1913),260.
6.    

skn-rbt LD50:10 g/kg

    TXAPA9    Toxicology and Applied Pharmacology. 28 (1974),313.

Cyclohexyl acetate Consensus Reports

Reported in EPA TSCA Inventory.

Cyclohexyl acetate Safety Profile

Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. Human systemic effects by inhalation: conjunctiva irritation and unspecified respiratory system changes. A systemic irritant to humans. A skin and eye irritant. Flammable liquid when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Xi: Irritant
Risk Statements: 38: Irritating to the skin 
Safety Statements: 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection 
RIDADR: UN 2243 3/PG 3
WGK Germany: 1
RTECS: AG5075000
HazardClass: 3.2
PackingGroup: III

Cyclohexyl acetate Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

Cyclohexyl acetate Specification

 Cyclohexyl acetate (622-45-7) should be tightly closed in a well-ventilated place. Protective closing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled.

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