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| Name |
Cyclopiazonic acid |
EINECS | N/A |
| CAS No. | 18172-33-3 | Density | 1.42g/cm3 |
| PSA | 73.40000 | LogP | 2.76580 |
| Solubility | Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water. | Melting Point |
245-246℃ |
| Formula | C20H20 N2 O3 | Boiling Point | 598.6°Cat760mmHg |
| Molecular Weight | 336.39 | Flash Point | 315.8°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | 25 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
9H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one,10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aa,11ab,11ba)- (8CI); Cyclopiazonic acid; NSC 117181; a-Cyclopiazonic acid |
Cyclopiazonic acid Chemical Properties
Molecular Formula: C20H20N2O3
Molar mass: 336.38 g/mol
EINECS: 243-798-8
Density: 1.42 g/cm3
Flash Point: 315.8 °C
Index of Refraction: 1.715
Boiling Point: 598.6 °C at 760 mmHg
Vapour Pressure: 3.56E-15 mmHg at 25 °C
Melting point: 245-246 °C
Storage temp: -20 °C
Appearance: Off-white powder or crystals
Solubility: DMSO: soluble
Form: Powder
Color: White to off-white
Product categories of Cyclopiazonic acid (CAS NO.18172-33-3): Calcium signaling
Structure of Cyclopiazonic acid (CAS NO.18172-33-3):
XLogP3-AA: 3.1
H-Bond Donor: 2
H-Bond Acceptor: 4
Canonical SMILES: CC(=O)C1=C(N2C(C1=O)C3C(C2(C)C)CC4=C5C3=CNC5=CC=C4)O
InChI: InChI=1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,1617,21,25H,7H2,1-3H3
InChIKey: RLOAZVAJNNPPDI-UHFFFAOYSA-N
Cyclopiazonic acid Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| chicken | LD50 | oral | 12mg/kg (12mg/kg) | Poultry Science. Vol. 65(Suppl, | |
| mouse | LD50 | intraperitoneal | 13mg/kg (13mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Food and Chemical Toxicology. Vol. 23, Pg. 831, 1985. |
| mouse | LD50 | oral | 64mg/kg (64mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Research Communications in Chemical Pathology and Pharmacology. Vol. 55, Pg. 303, 1987. |
| rabbit | LDLo | intraperitoneal | 10mg/kg (10mg/kg) | BRAIN AND COVERINGS: CHANGES IN SURFACE EEG SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Food and Chemical Toxicology. Vol. 23, Pg. 831, 1985. |
| rat | LD50 | intraperitoneal | 2mg/kg (2mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Toxicology and Applied Pharmacology. Vol. 18, Pg. 114, 1971. |
| rat | LD50 | oral | 36mg/kg (36mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Toxicology and Applied Pharmacology. Vol. 18, Pg. 114, 1971. |
Carcinogenicity of Cyclopiazonic acid (CAS NO.18172-33-3) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65. You can see actual entry in RTECS for complete information.
Cyclopiazonic acid Consensus Reports
EPA Genetic Toxicology Program.
Cyclopiazonic acid Safety Profile
Poison by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: 
T
Risk Statements: 25
R25 :Toxic if swallowed.
Safety Statements: 36/37/39-45
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Cyclopiazonic acid Specification
Cyclopiazonic acid ,its cas register number is 18172-33-3. It also can be called 9H-Pyrrolo(1',2':2,3)isoindolo(4,5,6-cd)indol-9-one, 2,6,6a,7,11a,11b-hexahydro-10-acetyl-7,7-dimethyl-11-hydroxy-, (6a-alpha,11a,11b-alpha)- ; .alpha.-Cyclopiazonic acid ; alpha-Cyclopiazonic acid and alpha-Cyclopiazonate . Cyclopiazonic acid (CAS NO.18172-33-3) is hazardous,so the first aid measures and others should be known. Such as: When on the skin: first,should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly,Get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.
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