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| Name |
DALMANE |
EINECS | N/A |
| CAS No. | 1172-18-5 | Density | g/cm3 |
| PSA | 35.91000 | LogP | 5.10950 |
| Solubility | N/A | Melting Point |
190-220° |
| Formula | C21H23 Cl F N3 O . 2 Cl H | Boiling Point | 551.4°Cat760mmHg |
| Molecular Weight | 460.806 | Flash Point | 287.2°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Habituating and possibly addictive. An hypnotic and sedative. When heated to decomposition it emits very toxic fumes of F−, NOx, and Cl−. | Risk Codes | 22-33 |
| Molecular Structure |
|
Hazard Symbols |
|
| Synonyms |
2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-,dihydrochloride (9CI); 2H-1,4-Benzodiazepin-2-one,7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-,dihydrochloride (7CI,8CI); 7-Chloro-1-(2-diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride;7-Chloro-1-[2-(diethylamino)ethyl]-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-onedihydrochloride; Benozil; Dalmadorm; Dalmane; Dalmate; Dormodor; Felson;Flurazepam dihydrochloride; Flurazepam hydrochloride; ID 480; Insumin; Lunipax;NSC 78559; Ro 5-6901; Somlan |
DALMANE Chemical Properties
Product Name: Dalmane (CAS NO.1172-18-5)
Molecular Formula: C21H25Cl3FN3O
Molecular Weight: 460.8g/mol
Mol File: 1172-18-5.mol
Einecs: 214-630-0
Appearance: Odorless off-white to yellow crystalline powder
Boiling point: 551.4 °C at 760 mmHg
Storage Temperature: 2-8°C
Flash Point: 287.2 °C
Solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <6 mg/mL
Enthalpy of Vaporization: 83.17 kJ/mol
Vapour Pressure: 3.34E-12 mmHg at 25°C
XLogP3-AA:
H-Bond Donor: 2
H-Bond Acceptor: 4
Product Categories: Organics
DALMANE Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 186mg/kg (186mg/kg) | Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. | |
| mouse | LD50 | intravenous | 59100ug/kg (59.1mg/kg) | Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. | |
| mouse | LD50 | oral | 596mg/kg (596mg/kg) | Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. | |
| mouse | LD50 | subcutaneous | 440mg/kg (440mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 637, 1977. |
| rabbit | LD50 | oral | 568mg/kg (568mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969. |
| rat | LD50 | intraperitoneal | 152mg/kg (152mg/kg) | Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. | |
| rat | LD50 | intravenous | 38700ug/kg (38.7mg/kg) | Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. | |
| rat | LD50 | oral | 879mg/kg (879mg/kg) | Yakkyoku. Pharmacy. Vol. 26, Pg. 741, 1975. | |
| rat | LD50 | subcutaneous | 859mg/kg (859mg/kg) | Drugs in Japan Vol. 6, Pg. 706, 1982. |
DALMANE Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Habituating and possibly addictive. An hypnotic and sedative. When heated to decomposition it emits very toxic fumes of F−, NOx, and Cl−.
Safety Information of Dalmane (CAS NO.1172-18-5):
Hazard Codes: Xn.gif){kind=small}
Risk Statements: 22-33
22: Harmful if swallowed
33: Danger of cumulative effects
Safety Statements: 1/2-22-36-36/37/39
1: Keep locked up
2: Keep out of the reach of children
22: Do not breathe dust
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
DALMANE Specification
Dalmane ,its CAS NO. is 1172-18-5,the synonyms is 1,3-Dihydro-l)dihydrochloride ; 2H-1,4-benzodiazepin-2-one,7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluoropheny ; Benozil ; Dalmadorm ; Dalmadormhydrochloride ; Dormodor .
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