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DEXAMETHASONE ISONICOTINATE

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DEXAMETHASONE ISONICOTINATE

EINECS 218-866-5
CAS No. 2265-64-7 Density 1.34 g/cm3
PSA 113.79000 LogP 3.15540
Solubility Melting Point 256°C
Formula C28H32 F N O6 Boiling Point 676 °C at 760 mmHg
Molecular Weight 497.5552 Flash Point 362.6 °C
Transport Information Appearance
Safety Risk Codes
Molecular Structure Molecular Structure of 2265-64-7 (Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-[(4-pyridinylcarbonyl)oxy]-, (11b,16a)-) Hazard Symbols
Synonyms

Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl-, 21-isonicotinate(7CI,8CI);Ausixone;Auxiloson;Dexamethasone 21-(4-pyridinecarboxylate);Dexamethasone 21-isonicotinate;Dexamethasone isonicotinate;HE 111;Isonicotinic acid dexamethasone-21 ester;Isonicotinic acid, 21-ester with 9-fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione;Ketoren;Pyridine-4-carboxylic acid 21-dexamethasone ester;Pyridine-4-carboxylic acid-(dexamethasone-21')-ester;Voren;

 

DEXAMETHASONE ISONICOTINATE Chemical Properties

Product Name: Dexamethasone isonicotinate (CAS NO.2265-64-7)


Molecular Formula: C28H32FNO6
Molecular Weight: 497.56g/mol
Mol File: 2265-64-7.mol
Einecs: 218-866-5
Boiling point: 676 °C at 760 mmHg
Storage Temperature:
Flash Point: 362.6 °C
Density: 1.34 g/cm3
Surface Tension: 60.6 dyne/cm
Enthalpy of Vaporization: 104.26 kJ/mol
Vapour Pressure: 3.39E-19 mmHg at 25°C
XLogP3: 3.4
H-Bond Donor: 2
H-Bond Acceptor: 8

DEXAMETHASONE ISONICOTINATE Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 281mg/kg (281mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
mouse LD50 oral 3470mg/kg (3470mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
mouse LD50 subcutaneous 3211mg/kg (3211mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat LD50 intraperitoneal 313mg/kg (313mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat LD50 oral 3562mg/kg (3562mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.
rat LD50 subcutaneous 3297mg/kg (3297mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 20, Pg. 769, 1973.

DEXAMETHASONE ISONICOTINATE Safety Profile

Moderately toxic by intraperitoneal route. Experimental reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F and NOx.

DEXAMETHASONE ISONICOTINATE Specification

 Dexamethasone isonicotinate ,its CAS NO. is 2265-64-7,the synonyms is Dexamethasone isonicotinate ; Dexamethasone 21-isonicotinate ; 21-Isonicotinate ; Auxilson ; He111 ; Pyridin-4-carbonsaeure-(dexamethason-21')-ester ; Pyridine-4-carboxylicacid-(dexamethasone-21')ester ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(4-pyridinylcarbonyl)oxy-, (11.beta.,16.alpha.)- .

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