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DEXAMETHASONE SODIUM SULFATE

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DEXAMETHASONE SODIUM SULFATE

EINECS
CAS No. 466-11-5 Density g/cm3
PSA LogP
Solubility Melting Point
Formula C22H29FO8S•Na Boiling Point °Cat760mmHg
Molecular Weight 495.56 Flash Point °C
Transport Information Appearance
Safety Moderately toxic by intraperitoneal and subcutaneous routes. A steroid. When heated to decomposition it emits toxic fumes of F, SOx, and Na2O. Risk Codes
Molecular Structure Molecular Structure of 466-11-5 (DEXAMETHASONE SODIUM SULFATE			) Hazard Symbols
Synonyms

 

DEXAMETHASONE SODIUM SULFATE Chemical Properties

Product Name: Dexamethasone sodium sulfate (CAS NO.466-11-5)


Molecular Formula: C22H28FNaO8S
Molecular Weight: 494.5061 g/mol
Mol File: 466-11-5.mol
Einecs: 207-374-6
H-Bond Donor: 2
H-Bond Acceptor: 9
Rotatable Bond Count: 4
Tautomer Count: 6
Topological Polar Surface Area: 141
Heavy Atom Count: 33
Formal Charge: 0
Complexity: 1040
Defined Atom StereoCenter Count: 8
Covalently-Bonded Unit Count: 2

DEXAMETHASONE SODIUM SULFATE Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1660mg/kg (1660mg/kg)   Drugs in Japan Vol. 6, Pg. 477, 1982.
mouse LD50 oral > 7500mg/kg (7500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES

LIVER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 6, 1974.
mouse LD50 subcutaneous 2020mg/kg (2020mg/kg)   Drugs in Japan Vol. 6, Pg. 477, 1982.
rat LD50 intramuscular > 400mg/kg (400mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat LD50 intraperitoneal 2180mg/kg (2180mg/kg)   Drugs in Japan Vol. 6, Pg. 477, 1982.
rat LD50 intravenous 1gm/kg (1000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat LD50 oral > 7500mg/kg (7500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES

LIVER: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 6, 1974.
rat LD50 subcutaneous 3450mg/kg (3450mg/kg)   Drugs in Japan Vol. 6, Pg. 477, 1982.

DEXAMETHASONE SODIUM SULFATE Safety Profile

Moderately toxic by intraperitoneal and subcutaneous routes. A steroid. When heated to decomposition it emits toxic fumes of F, SOx, and Na2O.

DEXAMETHASONE SODIUM SULFATE Specification

 Dexamethasone sodium sulfate ,its CAS NO. is 466-11-5,the synonyms is Dexamethasone 21-(sodium sulphate) ; 9-Fluoro-11β,17-dihydroxy-16α-methyl-21-sodiosulfooxypregna-1,4-diene-3,20-dione .

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