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Product Name: Dihydrokavain (CAS NO.587-63-3)
Molecular Formula: C14H16O3
Molecular Weight: 232.28g/mol
Mol File: 587-63-3.mol
Appearance: White powder
Melting Point: 56-60ºC
Boiling point: 413.6 °C at 760 mmHg
Flash Point: 175.6 °C
Density: 1.12 g/cm3
Solubility: Soluble in DMSO and methanol.
Surface Tension: 41.3 dyne/cm
Enthalpy of Vaporization: 66.64 kJ/mol
Vapour Pressure: 4.75E-07 mmHg at 25°C
XLogP3-AA: 2.8
H-Bond Donor: 0
H-Bond Acceptor: 3
Product Categories: Coumarins
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intraperitoneal | > 250mg/kg (250mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962. |
dog | LD50 | intraperitoneal | > 200mg/kg (200mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962. |
mouse | LD50 | intraperitoneal | 325mg/kg (325mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962. |
mouse | LD50 | intravenous | 53mg/kg (53mg/kg) | BEHAVIORAL: ANTICONVULSANT | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 177, Pg. 261, 1969. |
mouse | LD50 | oral | 920mg/kg (920mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962. |
rabbit | LD50 | intraperitoneal | 350mg/kg (350mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 505, 1962. |
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating fumes.
Dihydrokavain ,its CAS NO. is 587-63-3,the synonyms is Dihydrokawain ; Marindinin ; 7,8-Dihydrokawain ; 5,6-Dihydro-4-methoxy-6-phenethyl-2h-pyran-2-on ; 6-Dihydro-4-methoxy-6-(2-phenylethyl)-(s)-2h-pyran-2-on ; Dihydro-kawai ; Dihydrokavain(p) .