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Demarol

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Demarol

EINECS 200-329-1
CAS No. 57-42-1 Density 1.055g/cm3
PSA 29.54000 LogP 2.15100
Solubility 6.55g/L(25 oC) Melting Point 270°C
Formula C15H21 N O2 Boiling Point 328.9°Cat760mmHg
Molecular Weight 247.337 Flash Point 111.6°C
Transport Information N/A Appearance N/A
Safety A human poison by an unspecified route. Poison experimentally by ingestion, subcutaneous, intravenous, intradermal, parenteral, and intraperitoneal routes. Human systemic effects by unspecified route: changes in sleep patterns and muscle weakness. Human reproductive effects by intramuscular route: effects on measurements and viability of newborn. A pharmaceutical painkiller. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS. Risk Codes 11-23/24/25-39/23/24/25
Molecular Structure Molecular Structure of 57-42-1 (MEPERIDINE) Hazard Symbols F,T
Synonyms

Isonipecoticacid, 1-methyl-4-phenyl-, ethyl ester (8CI);1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester;4-Carbethoxy-1-methyl-4-phenylpiperidine; Demerol; Ethyl1-methyl-4-phenylisonipecotate; Ethyl1-methyl-4-phenylpiperidine-4-carboxylate; Isonipecaine; Meperidine; Meperidol;Pethanol; Pethidin; Pethidine; Pethidineter; Petidina; Renaudin

Article Data 20

Demarol Chemical Properties

Chemical Name: Meperidine
IUPAC NAME: Ethyl 1-methyl-4-phenylpiperidine-4-carboxylate
CAS No.: 57-42-1
EINECS: 200-329-1
Molecular Formula: C15H21NO2
Molecular Weight: 247.33 g/mol
Density: 1.055 g/cm3 
Flash Point: 111.6 °C
Boiling Point: 328.9 °C at 760 mmHg
Storage temp.: -20°C
Following is the structure of Demarol (57-42-1):


Product Categories about Demarol (57-42-1) are Controlled Drug StandardsAlphabetic ; M ; MEA - MES ; Stable Isotopes
The chemical synonymous of Demarol (57-42-1) are Meperidine ; 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester ;  1-Methyl-4-phenyl-4-piperidinecarboxylicaciethylester ; 1-Methyl-4-phenylisonipecotic acid, ethyl ester ; 1-Methyl-4-phenylisonipecoticacid,ethylester ; 1-Methyl-4-phenylisonipecoticacidethylester ; 1-Methyl-4-phenyl-isonipecoticaciethylester

Demarol Toxicity Data With Reference

1.    

unr-man LDLo:15 mg/kg

    85DCAI    Poisoning; Toxicology, Symptoms, Treatments. 2 (1970),73.
2.    

unr-man TDLo:57 mg/kg:CNS

    NEJMAG    New England Journal of Medicine. 312 (1985),509.
3.    

orl-rat LD50:162 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 180 (1969),155.
4.    

ipr-rat LD50:87 mg/kg

    JAPMA8    Journal of the American Pharmaceutical Association, Scientific Edition. 47 (1958),323.
5.    

scu-rat LD50:113 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),600.
6.    

ivn-rat LD50:29 mg/kg

    DDREDK    Drug Development Research. 1 (1981),83.
7.    

idu-rat LD50:90 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 180 (1969),155.
8.    

orl-mus LD50:200 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 135 (1962),376.
9.    

ipr-mus LD50:150 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 135 (1962),376.
10.    

par-mus LD50:178 mg/kg

    JMCMAR    Journal of Medicinal Chemistry

Demarol Safety Profile

A human poison by an unspecified route. Poison experimentally by ingestion, subcutaneous, intravenous, intradermal, parenteral, and intraperitoneal routes. Human systemic effects by unspecified route: changes in sleep patterns and muscle weakness. Human reproductive effects by intramuscular route: effects on measurements and viability of newborn. A pharmaceutical painkiller. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.
Hazard Codes:
T: Toxic
F: Flammable
Risk Statements about Demarol (57-42-1):
R11 Highly flammable.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about Demarol (57-42-1):
S7 Keep container tightly closed.
S16 Keep away from sources of ignition.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25: Avoid contact with skin and eyes.

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