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Dextrophan tartrate

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Name

Dextrophan tartrate

EINECS N/A
CAS No. 143-98-6 Density g/cm3
PSA 138.53000 LogP 0.89570
Solubility N/A Melting Point 201-204°C
Formula C17H23NO•C4H6O6•H2O Boiling Point 410.4°Cat760mmHg
Molecular Weight 407.464 Flash Point 207.2°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. Risk Codes R22;
Molecular Structure Molecular Structure of 143-98-6 (DEXTRORPHAN D-TARTRATE) Hazard Symbols Xn
Synonyms

17methyl,tartrate(1:1)(salt),(+)morphinan3o;d3hydroxynmethylmorphinantartrate;dat;dextrophantartrate;DEXTRORPHANDTARTRATE((+)3HYDROXYNMETH;Dextrorphan,TartrateSalt;Dextrorphan,TartrateSalt

 

Dextrophan tartrate Chemical Properties

Product Name: Dextrophan tartrate (CAS NO.143-98-6)


Molecular Formula: C21H29NO7
Molecular Weight: 407.45746g/mol
Mol File: 143-98-6.mol
Appearance: White Solid
Boiling point: 647.6 °C at 760 mmHg
Storage Temperature: −70°C
Flash Point: 345.4 °C
Enthalpy of Vaporization: 100.34 kJ/mol
Vapour Pressure: 1.19E-17 mmHg at 25°C
H-Bond Donor: 5
H-Bond Acceptor: 8
Structure Descriptors of Dextrophan tartrate (CAS NO.143-98-6):
  Canonical SMILES: CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O.C(C(C(=O)O)O)(C(=O)O)O
  Isomeric SMILES: CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
  InChI: InChI=1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m11/s1 
  InChIKey: RWTWIZDKEIWLKQ-XCPWPWHNSA-N
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals

Dextrophan tartrate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 42mg/kg (42mg/kg)   "Synthetic Analgesics," Oxford, Pergamon Press, 1966Vol. 2, Pg. 77, 1966.
mouse LD50 oral 385mg/kg (385mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
mouse LD50 parenteral 17414ug/kg (17.414mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 145, Pg. 11, 1964.
mouse LD50 subcutaneous 350mg/kg (350mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rabbit LD50 intravenous 27500ug/kg (27.5mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: REGIDITY
Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 oral 1100mg/kg (1100mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.
rat LD50 subcutaneous 800mg/kg (800mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 109, Pg. 189, 1953.

Dextrophan tartrate Safety Profile

Poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Dextrophan tartrate (CAS NO.143-98-6):
Hazard Codes: XnHarmful
Risk Statements: 22  
22:  Harmful if swallowed 

Dextrophan tartrate Specification

 Dextrophan tartrate ,its CAS NO. is 143-98-6,the synonyms is 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol tartrate, d- ; Ro 1-6794 ; d-3-Hydroxy-N-methylmorphinan tartrate ; Morphinan-3-ol, 17-methyl-, tartrate (1:1) (salt), (+)- .

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