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Name |
Diclofenamide |
EINECS | 204-440-6 |
CAS No. | 120-97-8 | Density | 1.782 g/cm3 |
PSA | 137.08000 | LogP | 3.85040 |
Solubility | N/A | Melting Point |
239-241oC |
Formula | C6H6Cl2N2O4S2 | Boiling Point | 590.5 °C at 760 mmHg |
Molecular Weight | 305.163 | Flash Point | 310.9 °C |
Transport Information | N/A | Appearance | white or nearly white crystalline powder |
Safety | 36 | Risk Codes | 63 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
m-Benzenedisulfonamide,4,5-dichloro- (6CI,7CI,8CI);1,3-Disulfamoyl-4,5-dichlorobenzene;1,3-Disulfamyl-4,5-dichlorobenzene;3,4-Dichloro-5-sulfamylbenzenesulfonamide;4,5-Dichloro-1,3-disulfamoylbenzene;4,5-Dichloro-m-benzenedisulfonamide;Antidrasi;Daramide;Daranide;Dichlorophenamide;Dichlorphenamide;Diclofenamid; |
Article Data | 3 |
4,5-dichloro-1,3-benzenedisulfonyl chloride
dichlorophenamide
Conditions | Yield |
---|---|
With ammonia |
IUPAC Name: 4,5-Dichlorobenzene-1,3-disulfonamide
Synonyms of Diclofenamide (CAS NO .120-97-8): 1,3-Benzenedisulfonamide, 4,5-dichloro- ; 1,3-Disulfamoyl-4,5-dichlorobenzene ; 1,3-Disulfamyl-4,5-dichlorobenzene ; 3,4-Dichloro-5-sulfamylbenzenesulfonamide ; 4,5-Dichloro-1,3-benzenedisulfonamide ; 4,5-Dichloro-1,3-disulfamoylbenzene ; 4,5-Dichloro-3-benzenedisulfonamide ; 4,5-Dichloro-m-benzendisulfonamide
Molecular Structure:
Molecular Formula: C6H6Cl2N2O4S2
Molecular Weight: 305.16
CAS NO : 120-97-8
EINECS : 204-440-6
H bond acceptors: 6
H bond donors: 4
Freely Rotating Bonds: 2
Polar Surface Area: 91.52 Å2
Index of Refraction: 1.634
Molar Refractivity: 61.28 cm3
Surface Tension: 69.7 dyne/cm
Density: 1.782 g/cm3
Flash Point: 310.9 °C
Melting Point: 239-241 °C
Enthalpy of Vaporization: 88.1 kJ/mol
Boiling Point: 590.5 °C at 760 mmHg
Vapour Pressure: 6.43E-14 mmHg at 25°C
Appearance: white or nearly white crystalline powder.
SMILES: Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N
InChI: InChI=1/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) Copy InChIKey: GJQPMPFPNINLKP-UHFFFAOYAI
Std. InChI: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) Std. InChIKey: GJQPMPFPNINLKP-UHFFFAOYSA-N
Solubility: soluble in ethanol, soluble in alkaline solution, almost insoluble in water or chloroform. odorless and taste slightly bitter.
Product Categories of Diclofenamide (CAS NO.120-97-8): It is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.
Diclofenamide (CAS NO.120-97-8) is inhibitor of carbonic anhydrase , can lower intraocular pressure and diuretic effect. But the diuretic effect will be negligible, mainly for the treatment of glaucoma to reduce intraocular pressure. It is used also used as intermediate.
Diclofenamide (CAS NO .120-97-8) can be derived by chlorosulfonation and amination of o-dichlorobenzene.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 200mg/kg (200mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969. | |
mouse | LD50 | intraperitoneal | 304mg/kg (304mg/kg) | Therapie. Vol. 19, Pg. 1423, 1964. | |
mouse | LD50 | intravenous | 643mg/kg (643mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969. | |
mouse | LD50 | oral | 1710mg/kg (1710mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 41, 1969. | |
rat | LD50 | intraperitoneal | 1244mg/kg (1244mg/kg) | Drugs in Japan Vol. -, Pg. 446, 1990. | |
rat | LD50 | oral | 10070mg/kg (10070mg/kg) | Drugs in Japan Vol. -, Pg. 446, 1990. |
Hazard Codes: Xn
Risk Statements: 63
R63: Possible risk of harm to the unborn child.
Safety Statements: 36
S36: Wear suitable protective clothing.
RTECS: CZ9200000
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and SOx.