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| CAS No.: | 128-46-1 |
|---|---|
| Name: | Dihydrostreptomycin |
| Molecular Structure: | |
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| Formula: | C21H41N7O12 |
| Molecular Weight: | 583.596 |
| Synonyms: | Streptomycin,deoxydihydrohydroxy- (6CI,7CI);Streptomycin, dihydro- (8CI);2,4-Diguanidino-3,5,6-trihydroxycyclohexyl-5-deoxy-2-O-(2-deoxy-2-methylamino-a-L-glucopyranosyl)-3-hydroxymethyl-b-L-lyxo-pentanofuranoside;Abiocine;DHSM;DST;Vibriomycin; |
| EINECS: | 204-888-2 |
| Density: | 1.99 g/cm3 |
| Melting Point: | >300 °C |
| Boiling Point: | 954.5 °C at 760 mmHg |
| Flash Point: | 531.1 °C |
| Appearance: | Slightly beige solid. |
| PSA: | 334.59000 |
| LogP: | -5.17560 |
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Chemistry
Chemical Name: Dihydrostreptomycin
IUPAC NAME: 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine
CAS No.: 128-46-1
EINECS: 204-888-2
RTECS Class: Mutagen
Molecular Formula: C21H41N7O12
Molecular Weight: 583.59 g/mol
Density: 1.98 g/cm3
Flash Point: 531.1 °C
Boiling Point: 954.5 °C at 760 mmHg
Dihydrostreptomycin (128-46-1) is an antibiotic.Following is the structure:
The chemical synonymous of Dihydrostreptomycin (128-46-1) are Dihydrostreptomycin ; Dihydrostreptomycine sulphate ; Dihydrostreptomycinesulphatesterileusp
Toxicity Data With Reference
| 1. | cyt-mus-par 100 mg/kg | NULSAK Nucleus (Calcutta). 2 (1971),161. | ||
| 2. | ivn-rat LD50:200 mg/kg | JOBAAY Journal of Bacteriology. 53 (1947),205. | ||
| 3. | ipr-mus LD50:533 mg/kg | UPJOH* Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory .(Kalamazoo, MI.: )1971,2(6). | ||
| 4. | scu-rat LD50:1100 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 12 (1962),597. | ||
| 5. | ivn-mus LD50:200 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 1 (1980),96. | ||
| 6. | ipr-mus LD50:533 mg/kg | UPJOH* Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory .(Kalamazoo, MI.: )1971,2(6). | ||
| 7. | scu-mus LD50:1180 mg/kg | ACHTA6 Antibiotica et Chemotherapia. 11 (1963),2. | ||
| 8. | ivn-mus TDLo:200 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 1 (1980),96. | ||
| 9. | ims-mus LD50:350 mg/kg | AIMDAP Archives of Internal Medicine. 119 (1967),493. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Poison by intravenous and intramuscular routes. Moderately toxic by subcutaneous and intraperitoneal routes. Human teratogenic effects by unspecified route: developmental abnormalities of the eye and ear. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. A derivative of streptomycin; has anesthetic properties. When heated to decomposition it emits toxic fumes of NOx.
Attention:
1. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation.