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Epidermal growth factor

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Name

Epidermal growth factor

EINECS 263-468-7
CAS No. 62229-50-9 Density N/A
PSA 0.00000 LogP 0.00000
Solubility N/A Melting Point N/A
Formula C257H381N73O83S7 Boiling Point N/A
Molecular Weight 6045.66934 Flash Point powder
Transport Information N/A Appearance N/A
Safety Human mutation data reported. Risk Codes N/A
Molecular Structure Molecular Structure of 62229-50-9 (EPIDERMAL GROWTH FACTOR, HUMAN) Hazard Symbols B
Synonyms

Urogastrone (8CI);Anthelone U;EGF;Gastrone, uro-;Gastrone, g-uro-;Kutrol;Uroanthelone;Uroenterone;Urogastron;Epidermal growth factor;

 

Epidermal growth factor Chemical Properties

Product Name: Epidermal growth factor
EINECS of Epidermal growth factor (CAS NO.62229-50-9): 263-468-7 
Storage tempreture: 2-8 °C
Form: Powder

Epidermal growth factor History

The discovery of EGF won Stanley Cohen a Nobel Prize in Physiology and Medicine in 1986, and in 1989, Epidermal growth factor (CAS NO.62229-50-9) was patented for cosmetic use by Greg Brown.

Epidermal growth factor Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 7900mg/kg (7900mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #85-23325,
mouse LD50 intraperitoneal 5080mg/kg (5080mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #85-23325,
mouse LD50 intravenous 2850mg/kg (2850mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #85-23325,
mouse LD50 oral 12600mg/kg (12600mg/kg)   Drugs in Japan Vol. 6, Pg. 96, 1982.
rat LD50 intravenous 1990mg/kg (1990mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #85-23325,
rat LD50 oral > 15gm/kg (15000mg/kg)   Drugs in Japan Vol. 6, Pg. 96, 1982.

Epidermal growth factor Safety Profile

Hazard Codes of Epidermal growth factor (CAS NO.62229-50-9): BiohazardB
WGK Germany: 3
RTECS: KB4518000
F: 10-21
Moderately toxic by intravenous route. Mildly toxic by ingestion.

Epidermal growth factor Specification

 Epidermal growth factor ,its cas register number is 62229-50-9. It also can be called EGF ; and beta-Urogastrone . Epidermal growth factor (CAS NO.62229-50-9) is a growth factor that plays an important role in the regulation of cell growth, and differentiation by binding to its receptor EGFR. It is a low-molecular-weight polypeptide first purified from the mouse submandibular gland, and results in cellular proliferation, differentiation, and survival. It acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. inhibiting it decreases cancer risk for the increased risk of cancer by EGF.

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