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| CAS No.: | 62229-50-9 |
|---|---|
| Name: | EPIDERMAL GROWTH FACTOR, HUMAN |
| Molecular Structure: | |
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| Formula: | C257H381N73O83S7 |
| Molecular Weight: | 6045.66934 |
| Synonyms: | Urogastrone (8CI);Anthelone U;EGF;Gastrone, uro-;Gastrone, g-uro-;Kutrol;Uroanthelone;Uroenterone;Urogastron;Epidermal growth factor; |
| EINECS: | 263-468-7 |
| Flash Point: | powder |
| Hazard Symbols: | B |
| Safety: | Human mutation data reported. |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Chemistry
Product Name: Epidermal growth factor
EINECS of Epidermal growth factor (CAS NO.62229-50-9): 263-468-7
Storage tempreture: 2-8 °C
Form: Powder
History
The discovery of EGF won Stanley Cohen a Nobel Prize in Physiology and Medicine in 1986, and in 1989, Epidermal growth factor (CAS NO.62229-50-9) was patented for cosmetic use by Greg Brown.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 7900mg/kg (7900mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| mouse | LD50 | intraperitoneal | 5080mg/kg (5080mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| mouse | LD50 | intravenous | 2850mg/kg (2850mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| mouse | LD50 | oral | 12600mg/kg (12600mg/kg) | Drugs in Japan Vol. 6, Pg. 96, 1982. | |
| rat | LD50 | intravenous | 1990mg/kg (1990mg/kg) | Japanese Kokai Tokyo Koho Patents. Vol. #85-23325, | |
| rat | LD50 | oral | > 15gm/kg (15000mg/kg) | Drugs in Japan Vol. 6, Pg. 96, 1982. |
Safety Profile
Hazard Codes of Epidermal growth factor (CAS NO.62229-50-9): 
B
WGK Germany: 3
RTECS: KB4518000
F: 10-21
Moderately toxic by intravenous route. Mildly toxic by ingestion.
Specification
Epidermal growth factor ,its cas register number is 62229-50-9. It also can be called EGF ; and beta-Urogastrone . Epidermal growth factor (CAS NO.62229-50-9) is a growth factor that plays an important role in the regulation of cell growth, and differentiation by binding to its receptor EGFR. It is a low-molecular-weight polypeptide first purified from the mouse submandibular gland, and results in cellular proliferation, differentiation, and survival. It acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. inhibiting it decreases cancer risk for the increased risk of cancer by EGF.