- Erythromycin
- Erythromycin E
- Erythromycin estolate
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| Name |
Erythromycin estolate |
EINECS | 222-532-4 |
| CAS No. | 3521-62-8 | Density | 1.0053 (rough estimate) |
| PSA | 271.96000 | LogP | 7.55400 |
| Solubility | Freely soluble in organic solvents, practically insoluble in water /n | Melting Point |
135-140 °C dec. |
| Formula | C52H97NO18S | Boiling Point | 827.7 °C at 760 mmHg |
| Molecular Weight | 1000.34 | Flash Point | 454.4 °C |
| Transport Information | N/A | Appearance | Long needles |
| Safety | 22-36-26 | Risk Codes | 22-42/43-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
Sulfuricacid, monododecyl ester;LP 35;Lauryl alcohol sulfate;Lauryl hydrogen sulfate; |
Erythromycin estolate Chemical Properties
Empirical Formula: C52H97NO18S
Molecular Weight: 1056.3875
EINECS: 222-532-4
Flash Point: 454.4 °C
Enthalpy of Vaporization: 136.89 kJ/mol
Boiling Point: 827.7 °C at 760 mmHg
Vapour Pressure: 8.87E-32 mmHg at 25 °C
Melting point: 135-140 °C
Appearance: Long needles
Structure of Erythromycin estolate (CAS NO.3521-62-8):
IUPAC Name: [(2S,3R,4S,6R)-4-(Dimethylamino)-2-[[(1R,2R,4R,6R,7R,8S,9R,12R,13S,14S)-9-ethyl-2,7,8-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,6,8,12,14-hexamethyl-5,11-dioxo-10-oxacyclotetradec-1-yl]oxy]-6-methyloxan-3-yl] propanoate ; Dodecyl hydrogen sulfate
Product Category of Erythromycin estolate (CAS NO.3521-62-8): Intermediates & Fine Chemicals;Pharmaceuticals
Erythromycin estolate Uses
Erythromycin estolate (CAS NO.3521-62-8) has been used as an antibacterial agent and is often used for people who have an allergy to penicillins.
Erythromycin estolate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | > 6450mg/kg (6450mg/kg) | Drugs in Japan Vol. -, Pg. 211, 1990. | |
| mouse | LD50 | subcutaneous | > 6450mg/kg (6450mg/kg) | Drugs in Japan Vol. -, Pg. 211, 1990. | |
| rat | LD50 | oral | 1447mg/kg (1447mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LD50 | subcutaneous | > 6450mg/kg (6450mg/kg) | Drugs in Japan Vol. -, Pg. 211, 1990. | |
| women | TDLo | unreported | 100mg/kg/5D-I (100mg/kg) | LIVER: CHANGE IN GALL BLADDER STRUCTURE OR FUNCTION | Clinical Pharmacology and Therapeutics Vol. 6, Pg. 788, 1965. |
Erythromycin estolate Safety Profile
Hazard Codes: 
Xn,
Xi
Risk Statements: 22-42/43-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 22-36-26
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Erythromycin estolate Specification
It is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin estolate (CAS NO.3521-62-8) inhibits the cytochrome P450 system, particularly the CYP3A4 isozyme, which can cause it to affect the metabolism of many different drugs. It is not recommended when using clindamycin containing products, even topical products such as duac or benzaclin. In general, the simultaneous use two different erythromycin derivatives should be avoided as drugs in this macrolide family share a common mechanism of action.
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