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2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With SbF5 | 83% |
With sulfuric acid; silica gel | |
With sulfuric acid; silica gel at 140℃; |
2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester
A
1-fluoroethane
B
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
antimony pentafluoride In neat (no solvent) | A n/a B 83% |
ethyl 3,3,3-trifluoro-2-hydroxypropanoate
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With sodium hypochlorite pentahydrate In acetonitrile at 20℃; for 0.5h; Reagent/catalyst; Solvent; | 69% |
ethyl 3,3,3-trifluoropyruvate ethylhemiketal
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With sulfuric acid under 16.5017 - 49.505 Torr; | 67% |
Conditions | Yield |
---|---|
With zinc In pyridine at 20℃; for 2h; other esters; other perfluoroalkyl iodide; | 38% |
With zinc In pyridine at 20℃; for 2h; | 38% |
With zinc In pyridine at 20℃; 1) pyridine, 20 deg C; | 38% |
Conditions | Yield |
---|---|
With hydrogenchloride Heating; |
allylbenzene
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
silver hexafluoroantimonate; (S)-SEGPHOS-PdCl2 In dichloromethane at 20℃; for 0.5h; Ene reaction; | 100% |
With silver hexafluoroantimonate; (R)-(2,2'-bis(diphenylphosphanyl)biphenyl)dichloroplatinum(II) In dichloromethane at -20℃; for 1h; | 83% |
ethyl-3,3,3-trifluoropyruvate
methylenecyclohexane
Conditions | Yield |
---|---|
silver hexafluoroantimonate; (S)-SEGPHOS-PdCl2 In dichloromethane at 20℃; for 0.25h; Ene reaction; | 100% |
With silver hexafluoroantimonate; [(R)-BINAPHANE]PdCl2 In dichloromethane at 20℃; for 1h; Inert atmosphere; optical yield given as %ee; enantioselective reaction; | 78% |
With silver hexafluoroantimonate; chiral SEGPHOS-Pd(II) In dichloromethane at 20℃; for 0.25h; Friedel-Crafts reaction; |
allylbenzene
ethyl-3,3,3-trifluoropyruvate
Conditions | Yield |
---|---|
With silver hexafluoroantimonate; chiral SEGPHOS-Pd(II) In dichloromethane at 20℃; for 0.5h; Friedel-Crafts reaction; | 100% |
Product Name: Ethyl trifluoropyruvate (CAS NO.13081-18-0)
Molecular Formula: C5H5F3O3
Molecular Weight: 170.09g/mol
Mol File: 13081-18-0.mol
Density: 1.328 g/cm3
Boiling point: 88.1°C at 760 mmHg
Flash point: 8.1°C
Index of Refraction:1.348
Molar Refractivity:27.47 cm3
Surface Tension: 24.3 dyne/cm
Enthalpy of Vaporization: 32.83 kJ/mol
Vapour Pressure: 62 mmHg at 25°C
Appearance:yellow to pale yellow clear liquid
IUPAC Name:ethyl 3,3,3-trifluoro-2-oxopropanoate
Hazard Codes:Xn,C,Xi
Xn:Harmful
C:Corrosive
Xi:Irritant
Risk Statements:
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection .
S16:Keep away from sources of ignition - No smoking.
RIDADR:UN 3272 3/PG 3
WGK Germany :3
Hazard Note:Corrosive
HazardClass3
PackingGroup:III