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Ethylmorphine

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Name

Ethylmorphine

EINECS 200-970-7
CAS No. 76-58-4 Density 1.31 g/cm3
PSA 41.93000 LogP 1.82910
Solubility 2.794g/L(20 oC) Melting Point 40-42°C
Formula C19H23 N O3 Boiling Point 472.2 ºC at 760 mmHg
Molecular Weight 313.397 Flash Point 239.4 ºC
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also (−)-MORPHINE. Risk Codes 22
Molecular Structure Molecular Structure of 76-58-4 (Morphinan-6-ol,7,8-didehydro-4,5-epoxy-3-ethoxy-17-methyl-, (5a,6a)-) Hazard Symbols HarmfulXn
Synonyms

Morphinan-6a-ol, 7,8-didehydro-4,5a-epoxy-3-ethoxy-17-methyl- (8CI);Morphine, 3-O-ethyl- (7CI); 3-Ethoxymorphine; 3-O-Ethylmorphine; Codethyline;Diohin; Ethylmorphine; Morphine, ethyl-

Article Data 12

Ethylmorphine Chemical Properties

Empirical Formula: C19H23NO3
Molecular Weight: 313.3908 
EINECS: 200-970-7 
Index of Refraction: 1.653
Density: 1.31 g/cm3
Flash Point: 239.4 °C
Enthalpy of Vaporization: 77.44 kJ/mol
Boiling Point: 472.2 °C at 760 mmHg
Vapour Pressure: 1.01E-09 mmHg at 25 °C 
storage temp.: 2-8 °C
Structure of Ethylmorphine (CAS NO.76-58-4):
                

Ethylmorphine Uses

 Ethylmorphine (CAS NO.76-58-4) has been invented in Germany at Merck in 1884 and was used as a weaker alternative to heroin for all indications. It is used as an antitussive to treat dry cough and also as a moderately strong analgesic. It is most widely used in ophthalmology for removing inflammation products from the eyes.

Ethylmorphine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 120mg/kg (120mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Annales Pharmaceutiques Francaises. Vol. 8, Pg. 261, 1950.
mouse LD50 oral 520mg/kg (520mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
mouse LD50 subcutaneous 136mg/kg (136mg/kg)   "Public Health Reports, Supplement." Vol. 138, Pg. 8, 1938.
rat LD50 intraperitoneal 110mg/kg (110mg/kg)   Pharmazie. Vol. 31, Pg. 655, 1976.
rat LD50 intravenous 62mg/kg (62mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 929, 1973.
rat LD50 oral 810mg/kg (810mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 929, 1973.
rat LD50 subcutaneous 200mg/kg (200mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 929, 1973.
 

Ethylmorphine Safety Profile

Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also (−)-MORPHINE.
 

Hazard Codes: HarmfulXn
Risk Statements: 22 
R22:Harmful if swallowed.
Safety Statements: 36/37/39-45 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Ethylmorphine Specification

 Ethylmorphine ,its cas register number is 76-58-4. It also can be called Ethomorphine ; Codethyline ; Dionine, and Ethyl morphine . It has a hydromorphone analogue, and a dihydromorphine analogue known as ethyldihydromorphine, and  is potentially habit-forming and can generate drug dependence of the codeine type.  Ethylmorphine (CAS NO.76-58-4) is 'less potent than morphine' but 'more potent than codeine' by a small percentage.Taking it in combination with alcohol or other drugs that have a suppressive effect on the central nervous system boosts both drugs' effects, creating a dangerous combination. It is converted to morphine in the human liver by the CYP450-isozyme CYP2D6, similarly to codeine. In most countries and internationally ethylmorphine and codeine are regulated much the same way.