Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Fazarabine |
EINECS | N/A |
CAS No. | 65886-71-7 | Density | 2.08g/cm3 |
PSA | 143.72000 | LogP | -2.58680 |
Solubility | N/A | Melting Point |
220 °C (decomp) |
Formula | C8H12N4O5 | Boiling Point | 534.5 °C at 760 mmHg |
Molecular Weight | 244.207 | Flash Point | 277 °C |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
1-b-D-Arabinofuranosyl-5-azacytosine;5-Aza-1-arabinosylcytosine;5-Azacytosine arabinoside;Fazarabine;Kymarabine;NSC 281272;ara-AC; |
Article Data | 3 |
The Fazarabine with the CAS number 65886-71-7 is also called 1-b-D-Arabinofuranosyl-5-azacytosine. The systematic name is 4-amino-1-(β-D-arabinofuranosyl)-1,3,5-triazin-2(1H)-one. Its molecular formula is C8H12N4O5. This chemical is a kind of organics. It should be stored in dry and cool environment.
The properties of the chemical are: (1)ACD/LogP: -1.99; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -2; (4)ACD/LogD (pH 7.4): -1.99; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.95; (8)ACD/KOC (pH 7.4): 1.96; (9)#H bond acceptors: 9; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 85.19 Å2; (13)Index of Refraction: 1.823; (14)Molar Refractivity: 51.08 cm3; (15)Molar Volume: 117 cm3; (16)Polarizability: 20.25×10-24cm3; (17)Surface Tension: 106.7 dyne/cm; (18)Enthalpy of Vaporization: 93.24 kJ/mol; (19)Vapour Pressure: 1.18×10-13 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1/N=C(\N=C/N1[C@@H]2O[C@@H]([C@@H](O)[C@@H]2O)CO)N
(2)InChI: InChI=1/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5+,6-/m1/s1
(3)InChIKey: NMUSYJAQQFHJEW-ARQDHWQXBX
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | intravenous | 1557ug/kg/72H (1.557mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: AGRANULOCYTOSIS | Proceedings of the American Association for Cancer Research. Vol. 29, Pg. 194, 1988. |