Basic Information | Post buying leads | Suppliers | Cas Database |
fluorometholone
Conditions | Yield |
---|---|
With methanol; sodium hydroxide at 0 - 5℃; for 5h; Reagent/catalyst; Temperature; | 96.3% |
6α-methyl-9,11β-epoxy-17α-hydroxy-pregna-1,4-diene-3,20-dione
fluorometholone
Conditions | Yield |
---|---|
With triethylamine tris(hydrogen fluoride) at 25℃; | 90% |
With hydrogen fluoride; water at -35℃; for 4h; | 80% |
Conditions | Yield |
---|---|
ueber mehrere Stufen; |
6α-methyl-17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione
fluorometholone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydroxide; dihydrogen peroxide / methanol / 9 h / 35 - 45 °C / Inert atmosphere 2.1: hydrogen fluoride / N,N-dimethyl-formamide / 3 h / -4 - 0 °C 2.2: 3 h / pH 7 View Scheme |
fluorometholone
Conditions | Yield |
---|---|
Stage #1: C22H28O4 With hydrogen fluoride In N,N-dimethyl-formamide at -4 - 0℃; for 3h; Stage #2: With ammonium hydroxide In N,N-dimethyl-formamide for 3h; pH=7; Temperature; pH-value; |
fluorometholone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: perchloric acid; 5,5-dibromohydantoin / water; acetone / 4 h / 0 - 5 °C 1.2: 3 h / 0 - 5 °C 2.1: hydrogen fluoride / water / 4 h / -25 - -20 °C 3.1: sodium hydroxide; methanol / 5 h / 0 - 5 °C View Scheme |
fluorometholone
Conditions | Yield |
---|---|
With acetic acid In acetone at 50 - 80℃; for 4h; pH=4 - 5; Reagent/catalyst; pH-value; Temperature; |
Molecular Structure:
Molecular Formula: C22H29FO4
Molecular Weight: 376.4617
IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a] phenanthren-3-one
Synonyms of Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11b)- (CAS NO.426-13-1): Fluorometholone [INN:BAN:JAN] ; FML-S Liquifilm ; Neo-Oxylone ; 9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione ; 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione ; AI3-52813 ; Cortilet ; Delmeson ; EINECS 207-041-5 ; FML Forte ; FML Liquifilm ; FML S.O.P. ; Flumetholon ; Fluor-Op ; Fluormetholone ; Fluormetholonum ; Fluorometholone ; Fluorometholonum ; Fluorometholonum [INN-Latin] ; Fluorometolona ; Fluorometolona [INN-Spanish] ; Fluorometolone ; Fluorometolone [DCIT] ; Fml ; Oxylone ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-6-alpha-methyl- ; Trilcin ; U 8614 ; UNII-SV0CSG527L ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
CAS NO: 426-13-1
Classification Code: Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Anti-allergic agents ; Drug / Therapeutic Agent ; Glucocorticoid ; Glucocorticoids ; Hormones ; Hormones, Hormone Substitutes, and Hormone Antagonists
Index of Refraction: 1.574
Molar Refractivity: 98.7 cm3
Molar Volume: 298.9 cm3
Surface Tension: 50.1 dyne/cm
Density: 1.25 g/cm3
Flash Point: 272.6 °C
Enthalpy of Vaporization: 92.22 kJ/mol
Boiling Point: 527.1 °C at 760 mmHg
Vapour Pressure of Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11b)- (CAS NO.426-13-1): 2.59E-13 mmHg at 25 °C
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rat | LD | oral | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974. | |
rat | LD | subcutaneous | > 2gm/kg (2000mg/kg) | Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2349, 1974. | |
rat | LD50 | intraperitoneal | 443mg/kg (443mg/kg) | Drugs in Japan Vol. -, Pg. 981, 1990. |
Hazard Codes of Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-6-methyl-, (6a,11b)- (CAS NO.426-13-1): Xn
Risk Statements:20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:36
S36: Wear suitable protective clothing.
WGK Germany:3
RTECS:TU3834100