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Fmoc-L-alpha-Alanine

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Name

Fmoc-L-alpha-Alanine

EINECS 252-660-6
CAS No. 35661-39-3 Density 282 g/cm3
PSA 79.12000 LogP 3.20260
Solubility Soluble in water. Melting Point 147-153 °C(lit.)
Formula C18H17NO4 Boiling Point 544.1 °C at 760 mmHg
Molecular Weight 311.337 Flash Point 282.9 °C
Transport Information N/A Appearance white to light yellow crystal powder
Safety 24/25-36/37/39-27-26 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 35661-39-3 (FMOC-Ala-OH) Hazard Symbols IrritantXi
Synonyms

(2S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]propanoicacid;(9-Fluorenylmethoxycarbonyl)-L-alanine;(S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]propionic acid;(S)-N-Fmoc-alanine;FMOC-Alanine;N-(9-Fluorenylmethoxycarbonyl)alanine;N-9-Fluorenylmethoxycarbonyl-L-alanine;NPC 14688;NSC 334296;Fmoc-Ala-OH;Fmoc-β-Ala-OH;

Article Data 48

Fmoc-L-alpha-Alanine Synthetic route

C32H27NO5

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With potassium phosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ascorbic acid In water; acetonitrile at 20℃; for 1h; Irradiation;100%
56-41-7

L-alanin

82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water at 20℃; for 18h;99%
With sodium carbonate In N,N-dimethyl-formamide for 0.166667h; Ambient temperature;96%
With sodium carbonate In 1,4-dioxane; water at 20℃; for 18h;
56-41-7

L-alanin

28920-43-6

(fluorenylmethoxy)carbonyl chloride

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
In water at 110℃; for 0.0833333h; Microwave irradiation; Green chemistry; chemoselective reaction;96%
In ethanol; water at 60℃; for 4h; chemoselective reaction;86%
56-41-7

L-alanin

polymer-bound Fmoc-O-succinimide

polymer-bound Fmoc-O-succinimide

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 24h;95%
56-41-7

L-alanin

1370440-36-0

N-(((9H-fluoren-9-yl)methoxy)carbonyloxy)-2-oxo-2-(piperidin-1-yl)acetimidoyl cyanide

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone93.2%
56-41-7

L-alanin

88744-04-1

(9-fluorenyl)methyl pentafluorophenyl carbonate

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone Ambient temperature;93%
56-41-7

L-alanin

1370440-32-6

N-(((9H-fluoren-9-yl)methoxy)carbonyloxy)-2-(ethylamino)-2-oxoacetimidoyl cyanide

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone92.6%
56-41-7

L-alanin

99503-04-5

Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester 9H-fluoren-9-ylmethyl ester

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With tertiary amine In 1,4-dioxane; water for 3h;91%
56-41-7

L-alanin

Carbonic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester 9H-fluoren-9-ylmethyl ester

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 2h;91%
ether-petroleum ether

ether-petroleum ether

56-41-7

L-alanin

28920-43-6

(fluorenylmethoxy)carbonyl chloride

35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Conditions
ConditionsYield
In 1,4-dioxane; sodium carbonate90.2%

Fmoc-L-alpha-Alanine Standards and Recommendations

APPEARANCE OF FMOC-l-ALANINE: White to off-white crystalline powder
ASSAY OF FMOC-L-AL: 99.0% min
OPTICAL ROTATION [a]20: -17.5 ° ~ -29.5°(C=1 in DMF)
SOLUTION CLARITY: clear
Fe: 10ppm max
HEAVY METALS 10ppm max
As: 2ppm max
LOSS ON DRYING: 0.5% max

Fmoc-L-alpha-Alanine Specification

The Fmoc-L-alpha-Alanine, with the CAS registry number 35661-39-3, is also known as NSC334296. It belongs to the product categories of Protected Amino Acids; Fluorenes, Flurenones; Amino Acids; Alanine [Ala, A]; Fmoc-Amino Acids and Derivatives; Amino Acids (N-Protected); Biochemistry; Fmoc-Amino Acids; Fmoc-Amino Acid Series. Its EINECS registry number is 252-660-6. This chemical's molecular formula is C18H17NO4 and molecular weight is 311.33188. Its IUPAC name is called 2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid. The product should be sealed and stored in cool and dry place.

Physical properties of Fmoc-L-alpha-Alanine: (1)ACD/LogP: 3.54; (2)ACD/LogD (pH 5.5): 1.52; (3)ACD/LogD (pH 7.4): 0.02; (4)ACD/BCF (pH 5.5): 2.78; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 19.31; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 5; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 5; (11)Index of Refraction: 1.607; (12)Molar Refractivity: 83.91 cm3; (13)Molar Volume: 242.7 cm3; (14)Surface Tension: 55.3 dyne/cm; (15)Density: 1.282 g/cm3; (16)Flash Point: 282.9 °C; (17)Enthalpy of Vaporization: 86.58 kJ/mol; (18)Boiling Point: 544.1 °C at 760 mmHg; (19)Vapour Pressure: 1.13E-12 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
(2)InChI: InChI=1S/C18H17NO4/c1-11(17(20)21)19-18(22)23-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16H,10H2,1H3,(H,19,22)(H,20,21)
(3)InChIKey: QWXZOFZKSQXPDC-UHFFFAOYSA-N

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