2-Phenyl-4-(aminomethyl)imidazoles as Potential Antipsychotic Agents. Synthesis and Dopamine D2 Receptor Binding

Article abstract of DOI:10.1021/jm00012a026

A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D₂ selective benzamide antipsychotics.The title compounds were synthesized and tested for blockade of <3H>YM-09151 binding in cloned African green monkey dopamine D₂ receptor preparations.The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)pyrroles.