Journal of Medicinal Chemistry p. 2251 - 2255 (1995)
Update date:2022-08-03
Topics:
Thurkauf, Andrew
Hutchison, Alan
Peterson, John
Cornfield, Linda
Meade, Robin
et al.
A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D2 selective benzamide antipsychotics.The title compounds were synthesized and tested for blockade of <3H>YM-09151 binding in cloned African green monkey dopamine D2 receptor preparations.The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)pyrroles.
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