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137-58-6

Basic Information
CAS No.: 137-58-6
Name: Lidocaine
Molecular Structure:
Molecular Structure of 137-58-6 (Lidocaine)
Formula: C14H22N2O
Molecular Weight: 234.34
Synonyms: 2',6'-Acetoxylidide,2-(diethylamino)- (8CI);2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide;Antrolin;Cuivasil;Dalcaine;ELA-Max;Esracaine;Isicaine;Jetocaine;Leostesin;Lidocadren;Lidoderm;Linisol;Maricaine;Penles;Remicaine;Solarcaine;Solcain;Xilina;Xycaine;Xyline;Xylocaine;Xylocitin;a-Diethylamino-2,6-acetoxylidide;
EINECS: 205-302-8
Density: 1.026 g/cm3
Melting Point: 66-69 °C
Boiling Point: 350.8 °C at 760 mmHg
Flash Point: 166 °C
Solubility: practically insoluble
Appearance: solid
Hazard Symbols: HarmfulXn
Risk Codes: 22
Safety: 22-26-36
Transport Information:
PSA: 32.34000
LogP: 2.65670
Synthetic route
109-89-7

diethylamine

1131-01-7

2-chloro-N-(2,6-dimethylphenyl)acetamide

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 99℃; under 5171.62 Torr; Temperature; Flow reactor;98%
at 40℃; for 6h; Temperature;97%
In hexane at 60℃; Temperature; Reflux;91.1%
109-89-7

diethylamine

79-04-9

chloroacetyl chloride

87-62-7

2,6-dimethylaniline

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
Stage #1: chloroacetyl chloride; 2,6-dimethylaniline In toluene at 80 - 90℃; for 3h; Large scale;
Stage #2: With sodium carbonate; potassium iodide In water; toluene for 0.5h; Large scale;
Stage #3: diethylamine In water; toluene Solvent; Temperature; Reagent/catalyst; Large scale;
95.2%
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 120 - 130℃; under 12929 Torr;
7409-48-5

(2-diethylaminoethyl)amide

87-62-7

2,6-dimethylaniline

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
With dipotassium peroxodisulfate In water at 100℃; for 0.166667h; Microwave irradiation; Green chemistry;95%
3734-33-6

denatonium benzoate

A

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

B

2-diethylamino-N-(2,6-dimethyl-phenyl)-3-phenyl-propionamide

Conditions
ConditionsYield
at 250℃;
87-62-7

2,6-dimethylaniline

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; sodium acetate
2: benzene
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / chloroform / 0.02 h / Flow reactor
2: triethylamine / N,N-dimethyl-formamide / 0.19 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid; sodium acetate / water / 24 h / Reflux
2: triethylamine / 1,4-dioxane / 120 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 105 °C / 12929 Torr / Flow reactor
2: triethylamine / N,N-dimethyl-formamide / 99 °C / 5171.62 Torr / Flow reactor
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / 3 h / 20 °C
2: acetone / 8 h / Reflux
View Scheme

[(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(2-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt

A

90-01-7

salicylic alcohol

B

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
With alkaline phosphatase In water at 37℃; for 6h; pH=7.4; Enzyme kinetics; Enzymatic reaction;

[(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(2-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
With rat lung homogenate at 37℃; for 3h; Enzyme kinetics;

[(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(4-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt

A

623-05-2

(4-hydroxyphenyl)methanol

B

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
With alkaline phosphatase In water at 37℃; for 6h; pH=7.4; Enzyme kinetics; Enzymatic reaction;
178421-96-0

C14H22N2O*C56H98O35

A

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

B

51166-71-3

heptakis(2,6-di-O-methyl)cyclomaltoheptaose

Conditions
ConditionsYield
With pluronic copolymer F290 In water at 25℃; Equilibrium constant; Reagent/catalyst;
30280-35-4

N,N-diethylglycine methyl ester

87-62-7

2,6-dimethylaniline

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
With sodium methylate at 95℃; for 0.5h; Concentration; Temperature;
576-26-1

2.6-dimethylphenol

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonium hydroxide; 2,6-dimethylcyclohexanone; 5%-palladium/activated carbon / 5 h / 180 °C
2: sodium methylate / 0.5 h / 95 °C
View Scheme
81-20-9

2,6-dimethylnitrobenzene

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol / 20 - 25 °C
2.1: potassium carbonate / dichloromethane
2.2: 1 h / 20 °C
3.1: hexane / 60 °C / Reflux
View Scheme

2-(N-ethylacetamido)2',6'-dimethylacetanilide

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 20℃;176 mg
119072-54-7, 2769-71-3

2,6-dimethylphenyl isonitrile

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,2-dichloro-ethane / 45 °C
2: borane-THF / tetrahydrofuran / 20 °C
View Scheme
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

57-11-4

stearic acid

1001438-56-7

C14H22N2O*C18H36O2

Conditions
ConditionsYield
for 0.0833333h; Inert atmosphere; Heating;100%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

73-78-9

lidocaine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether100%
With hydrogenchloride; pyrographite In water; 1,2-dichloro-ethane for 0.333333h; pH=3.5; pH-value;88.72%
With hydrogenchloride In water; acetone at 20℃; pH=<= 4;80.6%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

150994-82-4

4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoic acid

2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-aminium 4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoate

Conditions
ConditionsYield
In acetonitrile at 50℃; for 6h;100%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

C14H17(2)H5N2O

Conditions
ConditionsYield
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 3h; Inert atmosphere;99%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

96-32-2

bromoacetic acid methyl ester

2-((2,6-dimethylphenyl)amino)-N,N-diethyl-N-(2-methoxy-2-oxoethyl)-2-oxoethan-1-aminium bromide

Conditions
ConditionsYield
In acetonitrile at 80℃; for 1h; Inert atmosphere;97%
In acetonitrile at 60℃;
526-95-4

gluconic acid

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-aminium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate

Conditions
ConditionsYield
In ethanol for 5h; pH=2 - 7;95%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

N-(4-chloro-2,6-dimethylphenyl)-2-(diethylamino)-acetamide

Conditions
ConditionsYield
With trichloroisocyanuric acid; brilliant green carbocation In acetonitrile at 20℃; for 0.166667h; Irradiation; regioselective reaction;94%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

2903-45-9

lidocaine N-oxide

Conditions
ConditionsYield
With perfluoro-cis-2-n-butyl-3-n-propyloxaziridine; HCFC-225ca,cb In dichloromethane at -60℃; for 0.333333h;93%
With dihydrogen peroxide In methanol at 20℃; for 42h;71%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane
With rat liver microsomes; NADPH In water Product distribution;
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

187283-17-6

(4-bromomethylbenzyl)carbamic acid tert-butyl ester

C27H40N3O3(1+)*Br(1-)

Conditions
ConditionsYield
at 80℃; for 0.166667h;91%
at 80℃; for 0.166667h;91%
590-97-6

acetoxymethyl bromide

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

N-(acetoxymethyl)-2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-aminium bromide

Conditions
ConditionsYield
In acetonitrile at 80℃; for 1h; Inert atmosphere;90%
In 1,2-dichloro-ethane at 100℃; for 6h; Sealed tube;40%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

47377-16-2

4-tetradecylbenzenesulfonic acid

lidocaine 4-tetradecylbenzenesulfonate

Conditions
ConditionsYield
In isopropyl alcohol Heating;90%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

373-68-2

tetramethylammonium fluoride

31058-85-2

2-(diethylamino)-N-(2,6-dimethylphenyl)-N-methylacetamide

Conditions
ConditionsYield
In toluene at 100℃; for 12h;88%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

79840-57-6

4-octadecylbenzenesulfonic acid

lidocaine 4-octadecylbenzenesulfonate

Conditions
ConditionsYield
In ethanol; water Heating;87%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

39942-49-9

2-diethylamino-N-(2,6-dimethyl-3-nitro-phenyl)-acetamide

Conditions
ConditionsYield
With sulfuric acid; nitric acid In water at 0 - 25℃; for 0.75h;86%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

C31H60O8S*C5H5N

C31H60O8S*C14H22N2O

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h;85%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

C14H15(2)H7N2O

Conditions
ConditionsYield
With d8-isopropanol; 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II) In toluene at 170℃; for 2h; Inert atmosphere; Microwave irradiation; Sealed tube;84%
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); d8-isopropanol In toluene at 170℃; under 12751.3 Torr; for 2h; Microwave irradiation; Inert atmosphere; Sealed tube;84%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

C14H20(2)H2N2O

Conditions
ConditionsYield
With tetrakis(tetrabutylammonium)decatungstate(VI); 2,4,6-Triisopropylthiophenol; water-d2; trifluoroacetic acid In acetonitrile Irradiation;84%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

21714-23-8

(2,6-dichlorophenyl)cyanamide

3375-31-3

palladium diacetate

K[Pd(2,6-Cl2pcyd)2(LC)]

Conditions
ConditionsYield
Stage #1: (2,6-dichlorophenyl)cyanamide With potassium hydroxide In ethanol Reflux;
Stage #2: 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide; palladium diacetate With triethylamine In ethanol at 20℃; for 48h; pH=7;
83.33%

ammonium hexafluorophosphate

52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

C24H36ClN2ORu(1+)*F6P(1-)

Conditions
ConditionsYield
Stage #1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide In acetone at 20℃; for 5h; Inert atmosphere; Schlenk technique;
Stage #2: ammonium hexafluorophosphate Inert atmosphere; Schlenk technique;
81.2%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

540-51-2

2-bromoethanol

2-(2,6-dimethylphenylamino)-N,N-diethyl-N-(2-hydroxyethyl)-2-oxoethanaminium bromide

Conditions
ConditionsYield
at 100℃; for 8h;81.2%
at 90℃; for 24h; Temperature; Sealed tube;31%
at 90℃; for 24h;27.6%
at 80℃;
20922-60-5

2,6-dimethylphenylcyanamide

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

3375-31-3

palladium diacetate

K[Pd(2,6-Me2pcyd)2(LC)]

Conditions
ConditionsYield
Stage #1: 2,6-dimethylphenylcyanamide With potassium hydroxide In ethanol Reflux;
Stage #2: 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide; palladium diacetate With triethylamine In ethanol at 20℃; for 48h; pH=7;
81.14%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

627-18-9

1-bromo-3-propanol

N-(2-(2,6-dimethylphenylamino)-2-oxoethyl)-N,N-diethyl-3-hydroxypropan-1-aminium bromide

Conditions
ConditionsYield
at 110℃; for 8h;80.3%
at 80℃;
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

2,6-diethylphenylcyanamide

3375-31-3

palladium diacetate

K[Pd(2,6-Et2pcyd)2(LC)]

Conditions
ConditionsYield
Stage #1: 2,6-diethylphenylcyanamide With potassium hydroxide In ethanol Reflux;
Stage #2: 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide; palladium diacetate With triethylamine In ethanol at 20℃; for 48h; pH=7;
79.25%

potassium cyanide

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

2-((1-cyanoethyl)(ethyl)amino)-N-(2,6-dimethyl-phenyl)acetamide

Conditions
ConditionsYield
With 2-Picolinic acid; iron(III) chloride; tert-Butyl peroxybenzoate; 18-crown-6 ether In acetonitrile at 50℃; for 48h;77%

dichlorobis(dimethyl sulfoxide)platinum(II)

137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

3,5-dichlorophenylcyanamide

potassium hydroxide

K[Pt(3,5-(Cl2)2pcyd)2(LC)]

Conditions
ConditionsYield
Stage #1: 3,5-dichlorophenylcyanamide; potassium hydroxide In ethanol Reflux;
Stage #2: dichlorobis(dimethyl sulfoxide)platinum(II); 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide With triethylamine In ethanol at 20℃; pH=Ca. 7;
76.55%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

N-(3-chloro-2,6-dimethylphenyl)-2-(diethylamino)acetamide

Conditions
ConditionsYield
With hydrogen fluoride; antimony pentafluoride; sodium chloride at -20℃;75%
With hydrogenchloride; [bis(acetoxy)iodo]benzene In water; 1,2-dichloro-ethane at 50℃; for 2h; Reagent/catalyst; regioselective reaction;60%
137-58-6

2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

108-24-7

acetic anhydride

2-(N-ethylacetamido)2',6'-dimethylacetanilide

Conditions
ConditionsYield
With 1H-imidazole; iodosylbenzene; chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III) In dichloromethane; acetonitrile at 20℃; for 3h;74%
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Chemistry

Molecular Structure:

Molecular Formula: C14H22N2O
Molecular Weight: 234.3373
IUPAC Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
Classification Code: Anesthetic [topical] ; Anesthetics ; Anesthetics, local ; Anti-arrhythmia agents ; Cardiovascular Agents ; Central Nervous System Agents ; Central Nervous System Depressants ; Drug / Therapeutic Agent ; Human Data ; Mutation data ; Peripheral Nervous System Agents ; Reproductive Effect ; Sensory System Agents
Product Categories: Chiral Reagents ; Intermediates & Fine Chemicals ; Pharmaceuticals
EINECS: 205-302-8
Melting Point: 66-69°C 
Index of Refraction: 1.547
Molar Refractivity: 72.42 cm3
Molar Volume: 228.3 cm3
Surface Tension: 39.1 dyne/cm
Density: 1.026 g/cm3
Flash Point: 166 °C
Enthalpy of Vaporization: 59.55 kJ/mol
Boiling Point: 350.8 °C at 760 mmHg
Vapour Pressure of Lidocaine (CAS NO.137-58-6) : 4.28E-05 mmHg at 25 °C

 

Uses

 Lidocaine (CAS NO.137-58-6) is an amide local anesthetic widely used in surface anesthesia, infiltration anesthesia, conduction anesthesia and epidural anesthesia.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 21mg/kg (21mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 413, 1992.
child TDLo oral 300mg/kg/5D-I (300mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Pediatric Emergency Care. Vol. 10, Pg. 344, 1994.
guinea pig LD50 subcutaneous 120mg/kg (120mg/kg)   Farmaco, Edizione Scientifica. Vol. 10, Pg. 883, 1955.
guinea pig LDLo intravenous 65mg/kg (65mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 130, Pg. 235, 1961.
human TDLo intravenous 23mg/kg (23mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archiv fuer Toxikologie. Vol. 28, Pg. 72, 1971.
man TDLo intravenous 1700ug/kg/2M- (1.7mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE
American Journal of Emergency Medicine. Vol. 4, Pg. 143, 1986.
man TDLo intravenous 8643ug/kg/4H- (8.643mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Annals of Internal Medicine. Vol. 97, Pg. 149, 1982.
mouse LD50 intraperitoneal 102mg/kg (102mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Medicinal Chemistry. Vol. 24, Pg. 1059, 1981.
mouse LD50 intravenous 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 269, 1958.
mouse LD50 oral 220mg/kg (220mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1275, 1966.
mouse LD50 subcutaneous 238mg/kg (238mg/kg)   Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985.
rabbit LDLo intravenous 41mg/kg (41mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
rat LD50 intraperitoneal 133mg/kg (133mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 243, Pg. 97, 1980.
rat LD50 intravenous 18mg/kg (18mg/kg)   United States Patent Document. Vol. #5264432,
rat LD50 oral 317mg/kg (317mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
rat LD50 subcutaneous 335mg/kg (335mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 188, 1974.
rat LD50 unreported 39400ug/kg (39.4mg/kg)   Farmakologiya i Toksikologiya Vol. 54(3), Pg. 32, 1991.
women TDLo intraspinal 1mL/kg (1mL/kg) BEHAVIORAL: EUPHORIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 442, 1990.
women TDLo intravenous 16mg/kg (16mg/kg) CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
European Journal of Clinical Pharmacology. Vol. 22, Pg. 129, 1982.
women TDLo oral 39mg/kg (39mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT

CARDIAC: CHANGE IN RATE
New England Journal of Medicine. Vol. 306, Pg. 381, 1982.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Safety Information of Lidocaine (CAS NO.137-58-6):
Hazard Codes:HarmfulXn
Risk Statements:22
R22:Harmful if swallowed 
Safety Statements:22-26-36
S22:Do not breathe dust
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing     
RIDADR:3249
WGK Germany:3
RTECS:AN7525000
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: blood pressure lowering, changes in heart rate, coma, convulsions, distorted perceptions, dyspnea, excitement, hallucinations, muscle contraction or spasticity, pulse rate, respiratory depression, toxic psychosis. An experimental teratogen. Other experimental reproductive effects. A local anesthetic. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Specification

First Aid Measures of Lidocaine (CAS NO.137-58-6):
Ingestion:If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Storage of Lidocaine (CAS NO.137-58-6):
Store in a cool, dry place. Keep container closed when not in use.
Synonyms of Lidocaine (CAS NO.137-58-6) are 2',6'-Acetoxylidide, 2-(diethylamino)- ; 2-(Diethylamino)-2',6'-acetoxylidide ; 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide ; 4-12-00-02538 (Beilstein Handbook Reference) ; Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- ;  Alphacaine ; Anbesol ; Anestacon ; BRN 2215784 ; Cappicaine ; Cito optadren ; Cuivasil ; DentiPatch ; Diethylaminoaceto-2,6-xylidide ; Duncaine ; ; ELA-Max ; Esracaine ; Gravocain ; HSDB 3350 ; Isicaina ; Isicaine ; Jetocaine ; L-Caine ; Leostesin ; Lida-Mantle ; Lidocaina ; Lidocainum ;Maricaine ; Remicaine ; Rucaina ; Solarcaine ; Solcain ;  Xilina ; Xilocaina ; Xycaine ; Xylestesin ; Xylocain ; Xylocaine ; Xylocitin ; Xyloneural (free base) ; Xylotox ; alfa-Dietilamino-2,6-dimetilacetanilide ; alfa-Dietilamino-2,6-dimetilacetanilide [Italian] ; alpha-Diethylamino-2,6-dimethylacetanilide